参芪扶正注射液对急性冠脉综合征患者Thl／Th2漂移的影响

目的探讨参芪扶正注射液对急性冠脉综合征（acute coronary syndrome,ACS）患者冠脉介入治疗术后外周血Thl／Th2漂移的影响及胸痹虚实证候的相关性。方法选取60例行经皮冠状动脉介入治疗的ACS患者,随机分为参芪扶正注射液组和常规治疗组。参芪扶正治疗组30例,在常规治疗组的基础上加用参芪扶正注射液,术前1d开始连续用药10d。两组于术前1d、术后1d、术后3d,术后10d抽取外周静脉血,应用酶联免疫吸附法（enzyme-1inked immunosorbent assay,ELISA）检测干扰素7（in-terferon-7,IFN-7）、白介素2（interleukin-2,IL-2）、白介素4（interleukin-4,IL-4）、白介素10（interleukin-10）,并进行ee医胸痹辨证分型。结果两组术前血清中INF-7、IL-2、IL-4、IL-10水平差异无统计学意义。两组术后1d、3d、10d血清IFN-Y、IL-2水平均较术前降低（P％0．05）,相同时段治疗组IFN-r、IL-2水平明显低于对照组（P〈0．05）,IL-4、IL-10在术前、术后无显著性改变。虚证纽II。-2、IFN-r水平均较实证纽明显增高（P〈0．05）。冠脉介入术前、术后证型虚实分布存在差异,介入治疗后气虚证增加,血瘀证、寒凝证减少。结论参芪扶正注射液能明显降低ACS患者介入术后Thl细胞因子水平,使Thl／Th2细胞恢复至相对平衡状态。

Effects of Shenqi Fuzheng Injection on Thl/Th2 Drift in Acute Coronary Syndrome

Objective To study the effects of Shenqi Fuzheng injection（SFI） on Thl/Th2 drift in patients （pts） with acute coro- nary syndrome （ACS） after percutaneous coronary intervention（PCI）. Methods Sixty pts with ACS after PCI were divided randomly into two groups：SFI groups （n= 30） treated with SFI and conventional medicines,and routine group （n=30） treated with conven tional medicines. The interferon - r/（IFN - r）, interleukin（IL）- 2, IL - 4, and IL - 10 in the serum were detected by ELISA at 1 day be- fore PCI, and 1 day, 3 days,and 10 days after PCI. The pts were classified according to traditional Chinese medicine（TCM） syndrome differentiations. Results There were no significant difference in levels of IFN - r,IL - 2,IL - 4 and IL - 10 in two grougs before PCI （P〉0.05）. The levels of IFN - r and IL - 4 in both groups at 1 day,3 days,and 10 days after PCI were lower than those before PCI （P〈0.05） ,and the levels of those in the SFI group were significantly lower than those in the controls at the corresponding time points （P〈0.05）. There no significant difference in the levels of IL - 4 and IL - 10 after PCI （P〈0. O5）. The levels of IFN - r and IL - 2 in the sufficiency syndrome were significant higher than that in the deficiency syndrome （P〉0.05）. PCI might have some in- fluence on TCM syndromes of ACS. Qi deficiency syndrome was increased,blood stasis syndrome and phlegm- turbid syndrome were decreased after PCI. Conclusion SFI could significantly decrease the production of Thl,and maintain the balance of Thl/Th2 in pts with ACS after PCI.