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| N-(4-乙氧羰基-4-取代丁酰基)-N-取代甘氨酸的合成 | |
| 引用本文： | 陈耀明,蔡纯一,龚康孙. N-(4-乙氧羰基-4-取代丁酰基)-N-取代甘氨酸的合成[J]. 药学学报, 1989, 24(12): 887-894 |
| 作者姓名： | 陈耀明 蔡纯一 龚康孙 |
| 作者单位： | 华西医科大学药学院,成都610041;*本校1987届硕士研究生 |
| 摘 要： | 本文报道9个估计具有血管紧张素转化酶抑制活性的N-(4-乙氧羰基-4-取代丁酰基)-N-取代甘氨酸及其相应叔丁酯的合成和鉴定。药理初试结果,化合物Ⅶ7和Ⅶ9显示明显降压活性。 |
| 关 键 词： | N-(4-乙氧羰基-4-取代丁酰基)-N-取代甘氨酸 N-取代甘氨酸叔丁酯 2-取代戊二酸α单酯 血管紧张素转化酶抑制剂 抗高血压药 |
| 收稿时间： | 1988-08-30 |
SYNTHESIS OF N-(4-CARBETHOXY-4-SUBSTITUTED BUTYRYL)-N-SUBSTITUTED GLYClNES |
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| YM Chen,CY Cai and KS Gong. SYNTHESIS OF N-(4-CARBETHOXY-4-SUBSTITUTED BUTYRYL)-N-SUBSTITUTED GLYClNES[J]. Acta pharmaceutica Sinica, 1989, 24(12): 887-894 | |
| Authors: | YM Chen CY Cai KS Gong |
| Abstract: | This paper reports the synthesis of nine N-(4-carbethoxy-4-substituted butyryl)-N-substituted glycines and their corresponding t-butyl esters. The former were expected to have inhibitory activity of angiotensin-converting enzyme. All of the compounds mentioned above were unreported in the literature. In preliminary test in rats, compounds VII7 and VII9 showed marked hypotensive activity. |
| Keywords: | t-Butyl ester of N-substituted glycine α-Monoester of 2-substituted glutaric acid Angiotensin-converting enzyme inhibitor (ACEI) Antihypertensive N-(4-Carbethoxy-4-substituted butyryl)-N-substituted glycine |
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