颈动脉内膜-中层厚度与2型糖尿病相关危险因素分析

目的研究2型糖尿病患者颈动脉内膜-中层厚度(IMT)的改变,探讨其与各种相关危险因素的关系.方法141例2型糖尿病患者分为合并高血压组(n=70)和非高血压组(n=71),采用高分辨率彩色多普勒超声显像仪测量颈动脉IMT,同时测定相关危险因素并进行统计学分析.以71例老年健康体检者作为正常对照组.结果糖尿病非高血压组和合并高血压组IMT、血总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FPG)、餐后血糖(PBG)和胰岛素敏感性(ISI)均显著高于正常对照组.糖尿病合并高血压组IMT、TC、LDL-C、FPG显著高于非高血压组.结论糖尿病和高血压同时存在加速动脉粥样硬化的进程.IMT测量对2型糖尿病心脑血管疾病高危患者,具有早期发现和筛选作用.

Study of Carotic Intima-Media Thickness and Risk Factors in Patients with Type 2 Diabetes Mellitus

Objective To investigate carotid artery intima-media thickness(IMT) and relation of risk factors in patients with type 2 diabetes mellitus(DM). Methods The IMT of carotid artery were assessed by high resolution Doppler ultrasonography in 141 patients with type 2 DM and 71 healthy controls,and the relation of risk factors was(analyzed) by multiple stepwise regression. Results The IMT,TC,LDL-C,FPG,PBG and ISI were obviously higher in diabetes and diabetes combined with hypertension than in the controls.The IMT,TC,LDL-C and PBG were obviously higher in diabetes combined with hypertension than that in diabetes without hypertension. Conclusion(Diabetes mellitus) and hypertension may accelerate atherosclerosis.Measure must of IMT is a way to detect early in patients of high risk factors with heart diseases.