| E钙粘附素在乳腺癌组织中的表达及其意义 |
| |
| 引用本文： | 周宝臣,张青松,李东坤,花连才.E钙粘附素在乳腺癌组织中的表达及其意义[J].中国综合临床,2004,20(10):915-916. |
| |
| 作者姓名： | 周宝臣 张青松 李东坤 花连才 |
| |
| 作者单位： | 063000,河北省唐山市,河北省开滦(集团)有限责任公司医院普外科 |
| |
| 摘 要： | 目的 探讨E钙粘附素与乳腺癌浸润、转移和预后的关系。方法 应用免疫组织化学方法检测 77例乳腺癌、15例乳腺增生症和 15例乳腺纤维腺瘤组织中E钙粘附素表达水平。结果 E钙粘附素在乳腺癌组织中的阳性率为 5 5 .8% ,明显低于乳腺增生症和乳腺纤维腺瘤组织 (P <0 .0 5 ) ;E钙粘附素与乳腺癌腋淋巴结有无转移、有无远处转移有关 (P <0 .0 5 )。结论 E钙粘附素在乳腺癌浸润和转移中可能起重要作用 ,且对判断乳腺癌预后有一定的指导意义。
|
| 关 键 词： | 乳腺肿瘤 E钙粘附素 预后 |
| 文章编号： | 1008-6315(2004)10-0915-02 |
| 修稿时间： | 2004年4月20日 |
Expression and clinical significance of E-cadherin in breast cancer |
| |
| Zhou Baochen,Zhang Qingsong,Li Dongkun,et al..Expression and clinical significance of E-cadherin in breast cancer[J].Clinical Medicine of China,2004,20(10):915-916. |
| |
| Authors: | Zhou Baochen Zhang Qingsong Li Dongkun |
| |
| Institution: | Zhou Baochen,Zhang Qingsong,Li Dongkun,et al.Department of General Surgery,the Hospital of Kailuan |
| |
| Abstract: | Objective To study the relationship between E-cadherin(E-Cad)and infiltration metastasis and proghosis of breast cancer.Methods Immunohistochemical assay was used to investigate the expression of E-Cad in 77 cases of breast cancer,15 cases of breast fibroadenoma and 15 cases of breast proliferation.Results The positive rate of E-Cad was 55.8%,which was lower than that in cases of breast fibroadenoma and breast proliferation (P<0.05).The expression of E-Cad was significantly related to lymph node status and distant metastasis (P<0.05).Conclusion The expression of E-Cad may play an important role in infiltration and metastasis of breast cancer,and it is helpful for evaluation of prognosis of breast cancer. |
| |
| Keywords: | Breast cancer E-Cadherin Prognosis |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
