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| 膀胱癌癌旁组织端粒酶活性检测的临床意义 | |
| 引用本文： | 宋永胜,潘春雨,陈明,杨威,符伟军. 膀胱癌癌旁组织端粒酶活性检测的临床意义[J]. 中华泌尿外科杂志, 2002, 23(6): 347-348 |
| 作者姓名： | 宋永胜 潘春雨 陈明 杨威 符伟军 |
| 作者单位： | 1. 110004,沈阳,中国医科大学附属第二医院泌尿外科 2. 110004,沈阳,中国医科大学附属第二医院血液研究室 3. 解放军第二零二医院 |
| 基金项目： | 辽宁省科委自然科学基金 (962 2 79) |
| 摘 要： | 目的 探讨膀胱癌癌旁组织端粒酶活性检测的临床意义。 方法 采用端粒重复序列扩增 (TRAP)法 ,检测 2 4例膀胱癌组织及癌旁组织中端粒酶活性表达。 结果 2 4例癌旁组织中端粒酶活性表达阳性 10例 (42 % ) ,癌旁组织端粒酶活性表达与原发灶癌病理分级分期相关 ,并与癌复发相关。 结论 膀胱癌癌旁组织端粒酶活性检测可作为判断膀胱癌预后的指标之一 |
| 关 键 词： | 膀胱肿瘤 癌 预后 端粒酶活性 |
| 修稿时间： | 2001-04-22 |
Telomerase activity in the tissue adjacent to bladder cancer and its significance |
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| SONG Yongsheng,PAN Chunyu,YANG Wei,et al.. Telomerase activity in the tissue adjacent to bladder cancer and its significance[J]. Chinese Journal of Urology, 2002, 23(6): 347-348 | |
| Authors: | SONG Yongsheng PAN Chunyu YANG Wei et al. |
| Affiliation: | SONG Yongsheng,PAN Chunyu,YANG Wei,et al. Department of Urology,The 2nd Hospital of China Medical University,Shenyang 110004,China |
| Abstract: | Objective To study the telomerase activity in the tissue adjacent to bladder cancer and to investigate its clinical significance. Methods Telomerase activity was detected with telomeric repeat amplification PCR (TRAP) assay. The telomerase activity in the tissue adjacent to bladder cancer was evaluated. Results Telomerase activity was positive in the tissue samples adjacent to bladder cancer in 10 of the 24 cases(42%). Telomerase activity in the adjacent tissue has been related with the tumour grades and stages. The tumour recurrence was also related with the telomerase activity in the adjacent tissue. Conclusions The detection of telomerase activity in the tissue adjacent to bladder cancer could be a prognostic marker for bladder tumor recurrence. |
| Keywords: | Bladder neoplasms Carcinoma Prognosis Telomerase activity |
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