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| 卡氏肺孢子虫病鼠发病与氧自由基的关系 | |
| 引用本文： | 崔昱,秦元华,陈红. 卡氏肺孢子虫病鼠发病与氧自由基的关系[J]. 中国公共卫生, 2005, 21(1): 56-58 |
| 作者姓名： | 崔昱 秦元华 陈红 |
| 作者单位： | 1. 大连医科大学寄生虫学教研室,116023 2. 大连市友谊医院妇产科 |
| 基金项目： | 辽宁省优秀青年骨干教师部分资金资助项目 |
| 摘 要： | 目的探讨卡氏肺孢子虫感染大鼠后氧自由基产生组织氧化损害与发病之间的关系。方法观察大鼠感染卡氏肺孢子虫后，肺、脑组织感染虫数、病理以及谷胱甘肽(GSH)、丙二醛(MDA)、黄嘌呤氧化酶(XOD)3项指标的变化。结果病鼠肺组织印片中有大量原虫，镜下见肺泡壁充血和炎性细胞浸润。肺泡腔内有大量炎性渗出液．一些病灶呈实变。肺组织和脑组织中MDA和XOD升高。而GSH下降。结论卡氏肺孢子虫病鼠发病除与虫体本身所致肺组织的炎性损伤外，还可能与该虫体在宿主组织内引发多种氧化酶类产生严重的氧自由基损害有关。 |
| 关 键 词： | 卡氏肺孢子虫 谷胱甘肽 丙二醛 黄嘌呤氧化酶 |
| 文章编号： | 1001-0580(2005)01-0056-03 |
| 修稿时间： | 2004-04-19 |
Relationship between oxidizing damage and pathogeny of mice with pneumocystis carinii pneumonia |
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| CUI Yu,QING Yuanhua,CHEN Hong The. Relationship between oxidizing damage and pathogeny of mice with pneumocystis carinii pneumonia[J]. Chinese Journal of Public Health, 2005, 21(1): 56-58 | |
| Authors: | CUI Yu QING Yuanhua CHEN Hong The |
| Affiliation: | CUI Yu,QING Yuanhua,CHEN Hong The department of Parasitology,Dalian Medical University |
| Abstract: | Objective To study the relationship between oxidizing damage and pathogeny of mice with Pneumocystis carinii pneumonia (PCP).Methods The pathology, infecting protozoa numbers and the challges of measuring value of GSH, MDA, XOD of Lung, brain tissue and serum of infected mice were observed.Results The film appeared a large number of protozoon, there were congestion and inflammation on alveolus wall. MDA and XOD rose and GSH dropped in lung and brain tissues of infected mice. Conclusion Except inflammation damage leaded by protozoa itsef, the pathogeny of PCP relates to oxidizing damages by oxygen free radicals. |
| Keywords: | pneumocystis carinii pneumonia GSH MDA XOD |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |