| 黄芩苷对白念珠菌芽管形成及黏附性的影响 |
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| 引用本文： | 汪长中,冯鑫,张晓露,朱倩,谢传奇,程惠娟,王艳,云云.黄芩苷对白念珠菌芽管形成及黏附性的影响[J].中国中药杂志,2010,35(23):3216-3218. |
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| 作者姓名： | 汪长中 冯鑫 张晓露 朱倩 谢传奇 程惠娟 王艳 云云 |
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| 作者单位： | 安徽中医学院,中西医结合临床学院,安徽,合肥,230038 |
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| 基金项目： | 国家自然科学基金项目(81073127);安徽省自然科学基金项目(090413092);安徽省高校省级自然科学研究重点项目(KJ2010A220) |
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| 摘 要： | 目的:研究黄芩苷对白念珠菌芽管形成、对白念珠菌黏附人口腔上皮细胞及阴道上皮细胞的影响.方法:将100,50,10 mg·L-1黄芩苷分别与白念珠菌悬液、白念珠菌与口腔上皮细胞混合液、白念珠菌与阴道上皮细胞混合液共同孵育,显微镜下计数芽管形成率、白念珠菌对口腔上皮细胞及阴道上皮细胞的黏附百分率.结果:100,50,10 mg·L-1黄芩苷均能抑制白念珠菌芽管形成及对口腔上皮细胞和阴道上皮细胞的黏附;白念珠菌标准株与临床株之间无显著性差异.结论:黄芩苷对体外白念珠菌的芽管形成及黏附性有较强抑制作用.
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| 关 键 词： | 黄芩苷 白念珠菌 芽管形成 黏附性 |
| 收稿时间： | 6/2/2010 12:00:00 AM |
Inhibitory effect of baicalin on germ tube formation and adhesion of Candida albicans |
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| WANG Changzhong,FENG Xin,ZHANG Xiaolu,ZHU Qian,XIE Chuanqi,CHENG Huijuan,WANG Yan and YUN Yun.Inhibitory effect of baicalin on germ tube formation and adhesion of Candida albicans[J].China Journal of Chinese Materia Medica,2010,35(23):3216-3218. |
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| Authors: | WANG Changzhong FENG Xin ZHANG Xiaolu ZHU Qian XIE Chuanqi CHENG Huijuan WANG Yan and YUN Yun |
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| Institution: | School of Integrated Taditional and Westen Medicine, Anhui University of Traditional Chinese Medicine, Hefei 230038, China;School of Integrated Taditional and Westen Medicine, Anhui University of Traditional Chinese Medicine, Hefei 230038, China;School of Integrated Taditional and Westen Medicine, Anhui University of Traditional Chinese Medicine, Hefei 230038, China;School of Integrated Taditional and Westen Medicine, Anhui University of Traditional Chinese Medicine, Hefei 230038, China;School of Integrated Taditional and Westen Medicine, Anhui University of Traditional Chinese Medicine, Hefei 230038, China;School of Integrated Taditional and Westen Medicine, Anhui University of Traditional Chinese Medicine, Hefei 230038, China;School of Integrated Taditional and Westen Medicine, Anhui University of Traditional Chinese Medicine, Hefei 230038, China;School of Integrated Taditional and Westen Medicine, Anhui University of Traditional Chinese Medicine, Hefei 230038, China |
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| Abstract: | Objective : To investigate the effects of baicalin against Candida albicans germ tube formation, and adherence to buccal epitherial and vaginal epitherial cells. Method : Various concentrations of baicalin(100,50,10 mg·L-1) were incubated with C. albicans suspension, the mixed suspension of C. albicans and human buccal epitherial cells, the mixed suspension of C. albicans and vaginal epitherial cells, respectively. The effects of baicalin on C. albicans germ tube formation, and adherence to buccal epitherial and vaginal epitherial cells were then assessed microscopically. Result : All concentrations of baicalin could inhibit C. albicans germ tube formation, and adherent to buccal epitherial and vaginal epitherial cells,while there was no significant difference between standard and clinical strains. Conclusion : Baicalin could inhibit C. albicans germ tube formation, and adherence to buccal epitherial and vaginal epitherial cells. |
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| Keywords: | baicalin Candida albicans germ tube formation adherence |
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