Atrial natriuretic peptide in human urine |
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| Authors: | K. Ando N. Umetani T. Kurosawa S. Takeda Y. Katoh F. Marumo |
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| Affiliation: | (1) Kitasato Biochemical Laboratories, Bristol-Myers, Sagamihara, Kanagawa, Japan;(2) Department of Medicine, Kitasato University School of Medicine, Sagamihara, Japan;(3) Second Department of Internal Medicine, Tokyo Medical and Dental University, Yushima, Tokyo, Japan |
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| Abstract: | ![]()
Summary A highly sensitive radioimmunoassay to measure atrial natriuretic peptide (ANP) concentration in urine has been established, and its clinical usefulness is presented. ANP in urine was stable at 4° C for several days and was easily measured by our radioimmunoassay. The average ANP excretion in 65 healthy persons was 25.0±1.4 ng/day (mean ± SEM) and the fractional excretion of ANP was 0.7±0.05%. In 14 patients with congestive heart failure, the average ANP excretion was 119.2±29.4 ng/day, which decreased to 53.3±11.0 after successful treatment.Abbreviations ANP atrial natriuretic peptide - hANP human atrial natriuretic peptide - RIA radioimmunoasay - NSB non specific bound - FEANP the fractional excretion of atrial natriuretic peptide - FENa the fractional excretion of sodium - SIADH the syngrome of inappropriate secretion of antidiuretic hormone |
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| Keywords: | Atrial natriuretic peptide Urine Human Renal disease Congestive heart failure |
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