埃索美拉唑治疗胃食管反流病40例疗效观察

目的探讨埃索美拉唑治疗胃食管反流病的临床疗效和方法。方法给予莫沙必利5mg,3次/d,清晨空腹口服埃索美拉唑镁40mg,1次/d,连用4周。结果治疗前及疗程结束后,由专人行胃镜检查,显效29例,有效8例,无效3例,总有效率92.5%.症状总体疗效显著改善（P〈0.005）。结论提示联用莫沙必利与埃索美拉唑镁治疗糜烂性反流性食管炎,作用互补,合理有效,不失为治疗糜烂性反流性食管炎的较好选择。

Observation of curative effect of Esomeprazole in treating 40 cases of incurable GERD

Objective Erosive reflux esophagitis refers to the digestibility inflammation caused by solute in stomach and duodenum contrary to esophagus. Dopamine antagonist has been used in clinical treatment of erosive reflux esophagitis. Some patients which use this treatment have not obvious effect. Methods Clinical experiment proves that by use mosapride 5 mg,3 times a day,and take esomeprazole 40 mg orally once a day in the morning for four weeks. Results There are 29 cases acting,8 cases effective and 2 cases ineffective,total effective rate of 92.5%. His clinical evaluation of the overall symptoms,was significant different （P0.005）compared the efficacy with pre-treatment by gastroscopy. Conclusion Tips the function of joint use of mosapride and esomeprazole treatment plays an complementary role with each other,it is rational and effective. Undoubtedly,this treatment is a better choice for erosive reflux esophagitis.