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Gastrointestinal involvement in Langerhans' cell histiocytosis (Histiocytosis X): A clinical report of three cases
Authors:R. M. Egeler  M. E. I. Schipper  H. S. A. Heymans
Affiliation:(1) Department of Paediatric Gastroenterology and Nutrition, University Hospital of Amsterdam Emma Kinderziekenhuis/Kinder AMC, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands;(2) Department of Pathology, University Hospital of Amsterdam, Emma Kinderziekenhuis/Kinder AMC, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands;(3) Department of Paediatrics, University Hospital of Groningen, Groningen, The Netherlands
Abstract:
The gastrointestinal tract may be involved in Langerhans' cell histiocytosis, either as part of a generalized disease or as a separate primary entitiy. Three patients with gastrointestinal involvement are described. One patient presented with a history of prolonged vomiting and diarrhoea with blood and mucus. In this case the diagnosis was based on colonic biopsies. Gastrointestinal tract involvement and its investigation in the diagnosis of Langerhans' cell histiocytosis are discussed.
Keywords:Langerhans' cell histiocytosis (Histiocytosis X)  Gastrointestinal involvement
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