Cerebrospinal Fluid Penetration and Pharmacokinetic/Pharmacodynamic Parameters of Intravenously Administered Colistin in a Case of Multidrug-Resistant Acinetobacter baumannii Meningitis |
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| Authors: | M. Jiménez-Mejías C. Pichardo-Guerrero F. Márquez-Rivas D. Martín-Lozano T. Prados J. Pachón |
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| Affiliation: | (1) Service of Infectious Diseases, University Hospital Virgen del Rocío, Avenida Manuel Siurot s/n, 41013 Seville, Spain,;(2) Service of Neurosurgery, University Hospital Virgen del Rocío, Avenida Manuel Siurot s/n, 41013 Seville, Spain,;(3) Service of Microbiology, University Hospital Virgen del Rocío, Avenida Manuel Siurot s/n, 41013 Seville, Spain, |
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| Abstract: | ![]()
Described here is a case of meningitis caused by multidrug-resistant Acinetobacter baumannii susceptible only to colistin, which was treated successfully with intravenous colistin sulfomethate sodium (5 mg/kg/day). The levels of colistin in serum and cerebrospinal fluid and the pharmacokinetic/pharmacodynamic parameters of colistin were determined. In this case, intravenously administered colistin penetrated cerebrospinal fluid (25% of serum levels) at levels sustaining bactericidal concentrations. Electronic Publication |
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