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| 依达拉奉对大鼠肝I/R损伤的保护作用 | |
| 引用本文： | 石臣磊|秦华东|石铁锋. 依达拉奉对大鼠肝I/R损伤的保护作用[J]. 中国普通外科杂志, 2010, 19(1): 28-31 |
| 作者姓名： | 石臣磊|秦华东|石铁锋 |
| 作者单位： | 哈尔滨医科大学附属第二临床医院普外四科; |
| 基金项目： | 黑龙江省攻关课题(GB07C32502) |
| 摘 要： | 目的探讨依达拉奉对大鼠肝缺血再灌注(I/R)损伤中的保护作用。方法将60只大鼠随机分为实验组和对照组,建立常温下部分肝脏I/R动物模型。在肝脏I/R开始时和1 h后对实验组大鼠给予依达拉奉注射液,对照组给予同等容量的生理盐水。再灌注0,2,4 h测定肝脏脂质过氧化反应物(LPO)浓度和肝脏酶学指标及TNF-α和E-selectin的mRNA,并行两组肝脏的病理学检查。结果再灌注2,4 h实验组大鼠肝脏LPO反应程度和肝脏酶指标检测值明显低于对照组(P0.05)。再灌注2 h肝TNF-αmRNA和E-selectinmRNA表达明显低于对照组(P0.05)。再灌注2 h实验组大鼠肝脏切片的E-selectin免疫反应性明显低于对照组。结论依达拉奉能抑制氧化应激反应,从而降低肝I/R损伤;并显著减少炎性细胞和黏附分子的产生,抑制炎性反应的发生。 |
| 关 键 词： | 再灌注损伤； 肝； 依达拉奉/治疗应用； 肿瘤坏死因子α； E-选择素 |
| 收稿时间： | 2009-08-13 |
| 修稿时间： | 2009-12-12 |
The Protective effect of Edaravone on ischemia reperfusion injury in rat liver |
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| SHI Chenlei|QIN Huadong|SHI Tiefeng. The Protective effect of Edaravone on ischemia reperfusion injury in rat liver[J]. Chinese Journal of General Surgery, 2010, 19(1): 28-31 | |
| Authors: | SHI Chenlei|QIN Huadong|SHI Tiefeng |
| Affiliation: | SHI Chenlei,QIN Huadong,SHI Tiefeng(the Fourth Department of General Surgery,the Second Affiliated Hospital,Harbin Medical University,Harbin 150086,China) |
| Abstract: | Objective To investigate the protective effect of edaravone on ischemia reperfusion injury(IRI) in rat liver.Methods Sixty rats were randomly divided into experimental group and controll groups(30 in each) after establishing animal liver IRI model with partial reperfusion injury under normal temperature.Just after initiation of reperfusion and 1h later,edaravone was administered in the experiment group,and the same volume of normal saline was administered in the control group.The lipid peroxidation(LPO) hep... |
| Keywords: | Reperfusion Injury Liver Edaravone/ther use Tomor Necrosis Factor-α E-selectin |
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