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Two novel phorbol esters from Croton tiglium L.
Authors:Wentong Dou  Yanping Hao  Junli Liu  Dan Yuan  Hongzheng Fu
Abstract:
To investigate the phytochemical constituents of aboveground parts of Croton tiglium L. (family Euphorbiaceae), its ingredients were isolated by repeated chromatography on silica gel, Sephadex LH-20, ODS and preparative HPLC. Their structures were identified based on 1D, 2D NMR and mass spectral analysis. A total of 10 phorbol esters were obtained. Among them, compound 1 (12-O-(2-methyl)butyryl-4α-deoxyphorbol-13-isobutyrate) and compound 10 (20-formyl-4α-deoxyphorbol-13-acetate) were two new compounds, and the other eight were known compounds.
Keywords:Croton tiglium L.  Chemical constituents  Phorbol esters  
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