探讨乌司他丁对急性肺损伤(ALI)疗效

目的：观察乌司他丁对急性肺损伤（ALI）的治疗效果.方法：选择急性肺损伤（ALI）患者40例,随机分为2组,对照组20例予以常规治疗,治疗组20例在常规治疗基础上加用乌司他丁,乌司他丁30万u静脉泵入,每8h一次,每天共90万u,连用14天.对比2组治疗有效率及治疗后3d、10d的血气分析变化及白细胞总数变化,同时观察心率、呼吸频率的变化.结果：治疗组有效率为75%,与对照组50%相比差异有统计学意义（P〈0.01）,治疗组PaO2、氧合指数高于对照组,差异有统计学意义（P〈0.01）.结论：乌司他丁应用有助于改善急性肺损伤（ALI）患者的呼吸功能及预后.

Approach the treatment effect of ulinastatin on acute lung injury

Objective： To observe the therapeutic effect of ulinastatin on acute lung injury. Methods Forty patients with ALI were randomly divided into treatment group （n = 20） and control group （n = 20）. Each group include 20 patients. The patients in control group were treated with conven- tional therapy, while the other 20 patients in treatment group were treated with extra ulinastatin. （300ku intravenously pumping,once every 8 hours, 900ku everyday,and continued for 14days）, The management effect - 2rote, PaO2, PaO2/FiO2 ,heart rates and breathing and total white blood cell frequency were analyzed, the day 3 and the day I0 in both groups. Results The effective rate was 75% in treatment group and 50% in control group. There was significant difference between two groups. The PaO2, PaO2/Fio2 of treatment group was significantly higher than that of control group（ P 〈 0.01）. Conclusion the usage of ulinastatin could improve the respiratory function and prognosis of ALI.