| HPLC法测定复方替硝唑溶液中替硝唑含量 |
| |
| 引用本文： | 廖海燕,钟元高,何德云,张涛,李佳,杜建红.HPLC法测定复方替硝唑溶液中替硝唑含量[J].解放军药学学报,2012,28(4):345-346. |
| |
| 作者姓名： | 廖海燕 钟元高 何德云 张涛 李佳 杜建红 |
| |
| 作者单位： | 成都军区药品仪器检验所,四川成都,610017 |
| |
| 摘 要： | 目的应用HPLC法建立复方替硝唑溶液中替硝唑含量测定方法。方法采用HPLC法,流动相:0.05 mol·L-1磷酸二氢钾(pH=3.5)-甲醇(80∶20),柱温:35℃,流速:1.0 ml·min-1,检测波长:310 nm。结果替硝唑线性回归方程为Y=20.466 X+2.5733,r=1(n=6);样品平均回收率为101.34%,RSD为1.04%。结论本法操作方便,定量准确,适合该制剂的含量测定。
|
| 关 键 词： | HPLC 复方替硝唑溶液 替硝唑 含量测定 |
HPLC Method for Determination of Tinidazole Content in Compund Tinidazole Solution |
| |
| LIAO Hai-yan
,
ZHONG Yuan-gao
,
HE De-yun
,
ZHANG Tao
,
LI Jia
,
DU Jian-hong.HPLC Method for Determination of Tinidazole Content in Compund Tinidazole Solution[J].Pharmaceutical Journal of Chinese People's Liberation Army,2012,28(4):345-346. |
| |
| Authors: | LIAO Hai-yan ZHONG Yuan-gao HE De-yun ZHANG Tao LI Jia DU Jian-hong |
| |
| Institution: | Institute for Drug and Instrument Control of Chengdu Military Region,Chengdu 610017,China |
| |
| Abstract: | Objective To establish a method for determination of tinidazole content in compound tinidazole solution using HPLC.Methods HPLC was used with the mobile phase composed of 0.05 mol · L-1 potassium dihyogen phosphate(pH=3.5)-methanol(80∶ 20) at the detection wavelength of 310 nm.Results The linear regression equation of tinidazole was Y=20.466X+2.5733,r=1(n=6).The average recovery of samples was 101.34%,RSD=1.04%.Coclusion HPLC method is user-friendly,quantitatively accurate and suitable for content determination. |
| |
| Keywords: | HPLC compound tinidazole solution tinidazole content determination |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
