扶正除疫颗粒对感染流感病毒小鼠的保护作用

目的观察扶正除疫颗粒对流感病毒小鼠的影响及体外抑菌、抗病毒作用。方法比较小鼠感染流感病毒的各组死亡率;观察体外抑菌作用;以Hep-2传代细胞株进行传代培养,观察扶正除疫颗粒最大无毒剂量T(D0)、细胞半数感染量(TCID50)以及不同剂量受试药物对感染病毒细胞的保护作用。结果扶正除疫颗粒组感染病毒动物死亡率低于阴性对照组;对多种细菌具有体外抑菌作用,对肺炎链球菌抑菌作用较明显;对病毒所致的细胞病变有一定减轻作用。结论扶正除疫颗粒对感染病毒动物有一定保护作用,还具有抑菌、抗病毒作用。

Protective Effect of Fuzheng Chuyi Granules on the Mice Infected with Influenza Virus

Objective To observe the influence of Fuzheng Chuyi Granules on the mice infected with influenza virus and to observe its antibiotic and antivirus actions in vitro.Methods The death rate of mice infected with influenza virus in each group was compared and antimicrobial activity of Fuzheng Chuyi Granules was observed in vitro.Hep-2 passage cells were subcultured to observe the protective effect of the maximal non-toxic dosage(TD0),the infective dose of 50% tissue culture(TCID50) and other different dosage of Fuzheng Chuyi Granules on cells infected virus.Results Compared with that in negative control group,the death rate of infected mice was lower in Fuzheng Chuyi Granules groups.Fuzheng Chuyi Granules had antibiotic action on bacteria in vitro,particularly on streptococcus pneumoniae.Meanwhile,Fuzheng Chuyi Granules could alleviate cytopathy induced by virus.Conclusion Fuzheng Chuyi Granules have a certain protective effect on the animal infected with virus,and also have antibiotic and antivirus actions.