蒙特卡罗方法评估冠状动脉介入术中患者器官剂量的转换系数

目的通过蒙特卡罗方法模拟计算剂量面积乘积(DAP)致相关器官吸收剂量的转换系数, 从而为评估冠状动脉介入术中患者的器官剂量提供便利。方法使用Geant4蒙特卡罗软件构建人体和辐射场模型, 模拟计算并得到器官吸收剂量转换系数。结果在冠状动脉造影(CAG)中, 肺、骨髓、肝脏、心脏的转换系数, 男性分别为(0.283 ± 0.068)、(0.169± 0.049)、(0.110 ± 0.077)、(0.080 ± 0.032)mGy/(Gy·cm2), 女性分别为(0.376 ± 0.121)、(0.192 ± 0.056)、(0.153 ± 0.105)、(0.102 ± 0.033)mGy/(Gy·cm2), 与经皮冠脉介入治疗(PCI)中对应器官的转换系数相近。不同介入术的DAP差异具有统计学意义(t=-6.012, P<0.05)。性别组间的DAP差异没有统计学意义(P>0.05)。结论器官吸收剂量的转换系数在同一性别组内与冠状动脉造影和经皮介入治疗的相关性较小, 但同一术组中女性的剂量转换系数通常高于男性。蒙特卡罗方法计算的剂量面积乘积(DAP)致器官吸收剂量的转换系...

Estimation on organ absorbed dose conversion coefficient for patients during coronary intervention procedure with Monte Carlo method

Objective To calculate the conversion coefficient from dose area product (DAP) to organ absorbed dose by Monte Carlo method in order to conveniently estimate doses to patient organ during coronary intervention procedure. Methods The Geant4 Monte Carlo simulation kit was used to calculate the organ absorbed dose conversion coefficients by simulating exposure scene. Results The conversion coefficients used in coronary angiography (CAG) for lung, bone marrow, liver and heart were (0.283±0.068), (0.169±0.049), (0.110±0.077) and (0.080±0.032) mGy/(Gy·cm²) for male, and (0.376±0.121), (0.192±0.056), (0.153±0.105), and (0.102±0.033) mGy/(Gy·cm²) for female, respectively. These were similar to those in the case of percutaneous coronary intervention (PCI). The DAPs for different interventional procedures were statistically significant (t=-6.012, P<0.05). The DAPs for difference gender groups had no statistically significant (P>0.05). Conclusions Conversion coefficient for organ absorbed dose has little correlation with CAG and PCI in the same sex group. Dose conversion coefficients for female group are greater than those for male group in the same procedure. Conversion coefficients from DAP to organ absorbed dose calculated with Monte Carlo method can provide convenience for rapidly estimating the organ absorbed dose to clinical patients.