| 亚洲人维生素D受体基因BsmI多态性与前列腺癌关系的Meta分析 |
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| 引用本文： | 李夏西,侯祺,曹加,汪嬿如,陆楷,郑少斌,罗荣城. 亚洲人维生素D受体基因BsmI多态性与前列腺癌关系的Meta分析[J]. 中国全科医学, 2012, 15(5): 490-492 |
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| 作者姓名： | 李夏西 侯祺 曹加 汪嬿如 陆楷 郑少斌 罗荣城 |
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| 作者单位： | 1. 南方医科大学,南方医院肿瘤中心,广东省广州市,510515
2. 南方医科大学,南方医院泌尿外科,广东省广州市,510515 |
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| 摘 要： | 目的探讨亚洲人群维生素D受体(VDR)基因位点BsmI(rs1544410)多态性与前列腺癌易感性的关系。方法检索PubMed、EMBase、中国生物医学文献数据库(CBM)、中国知网(CNKI)、维普中文科技期刊数据库(VIP)、万方数据平台从建库到2011年5月的文献,对所纳入的独立研究,运用RevMan 5.0.0软件进行Meta分析,Stata 11.0软件进行Begg’s检验。结果共纳入6篇病例对照研究,累计样本量为1 890例,其中病例组796例,对照组1 094例。Meta分析结果表明,等位基因B对前列腺癌有保护作用〔OR=0.69,95%CI(0.55,0.88),P=0.002〕;基因型BB/Bb也能显著降低前列腺癌的发生率〔OR=0.64,95%CI(0.49,0.83),P=0.001〕。结论亚洲人群VDR基因位点BsmI多态性与前列腺癌易感性相关,等位基因B可能对前列腺癌发病起保护作用。
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| 关 键 词： | 受体,骨化三醇 多态性,单核苷酸 前列腺肿瘤 Meta分析 |
Association between Polymorphisms of VDR BsmI and Prostate Cancer in the Asian Population: A Meta-analysis |
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| Affiliation: | LI Xia-xi,HOU Qi,CAO Jia,et al.Department of Oncology,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China |
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| Abstract: | Objective To investigate the association between VDR BsmI polymorphism(rs1544410) and prostate cancer in the Asian population.Methods PubMed,EMBase,CBM,CNKI,VIP,and Wanfang Data were searched for related clinical controlled trials.Meta-analysis was conducted by Revman 5.0.0 software,and Begg′s test was carried out using STATA 11.0 software.Results Six case-control studies(1 890 cases,including 796 patients and 1 094 controls) were included.According to meta-analysis,the B-allele displayed protective effects against prostate cancer(OR=0.69,95%CI(0.55,0.88),P=0.002) while BB/Bb genotypes significantly reduce the incidence of prostate cancer(OR=0.64,95%CI(0.49,0.83),P=0.001).Conclusion VDR BsmI polymorphism is associated with the susceptibility of prostate cancer.B-allele and the BB/Bb genotypes may play protective roles against prostate cancer. |
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| Keywords: | Receptors,calcitriol Polymorphism,single nucleotide Prostatic neoplasms Meta-analysis |
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