Parkinson’s disease therapy: treatment of early and late disease

Purpose To summarize the current strategies for the treatment of early and late Parkin son’s disease (PD).Data sources The presented guidelines are based on the review of the literature as well as th e author’s extensive experience with the treatment of 7000 patients with PD over the past 25 years.Results An analysis of reported data as well as personal experience suggest that while y oung patients seem to have a slower progression of the disease, they are at a hi gher risk for developing levodopa induced complications, such as motor fluctuati ons and dyskinesias. It is, therefore, prudent practice to delay levodopa thera py, particularly in younger patients, until the PD symptoms become troublesome a nd interfere with social or occupational functioning. Other strategies, such as the use of deprenyl, amantadine, trihexyphenidyl and dopamine agonists, should be employed before instituting levodopa therapy. Entacopone and dopamine agonis ts are useful in smoothing out levodopa related motor fluctuations. Surgical in terventions, such as pallidotomy and pallidal or subthalamic deep brain stimulat ion, are effective therapeutic strategies, but should be reserved only for patie nts in whom optimal medical therapy fails to provide satisfactory control of sym ptoms.Conclusion The medical and surgical treatment of patients with PD must be individualized an d tailored to the needs of the individual patient.

Parkinson's disease therapy: treatment of early and late disease

Purpose To summarize the current strategies for the treatment of early and late Parkinson's disease (PD) Data sources The presented guidelines are based on the review of the literature as well as the author's extensive experience with the treatment of 7000 patients with PD over the past 25 years Results An analysis of reported data as well as personal experience suggest that while young patients seem to have a slower progression of the disease, they are at a higher risk for developing levodopa induced complications, such as motor fluctuations and dyskinesias It is, therefore, prudent practice to delay levodopa therapy, particularly in younger patients, until the PD symptoms become troublesome and interfere with social or occupational functioning Other strategies, such as the use of deprenyl, amantadine, trihexyphenidyl and dopamine agonists, should be employed before instituting levodopa therapy Entacopone and dopamine agonists are useful in smoothing out levodopa related motor fluctuations Surgical interventions, such as pallidotomy and pallidal or subthalamic deep brain stimulation, are effective therapeutic strategies, but should be reserved only for patients in whom optimal medical therapy fails to provide satisfactory control of symptoms Conclusion The medical and surgical treatment of patients with PD must be individualized and tailored to the needs of the individual patient