430例肝硬化患者血小板参数和凝血指标的探讨

目的了解肝硬化患者血小板参数和凝血指标的变化及其与Child—Pugh肝功能分级的关系。方法分别采用全自动血液分析仪（KX-21N）和全自动血凝仪（CA-6000）测定430例肝硬化患者和65例健康对照者的血小板及其参数（PLT、MPV、PDW、PCT）和凝血指标（PT、AVTT、TT、FIB）的变化并进行比较。结果与健康对照组比较，肝硬化患者PLT、PCT显著下降，MPV、PDW显著升高，PT、AFTT、TT明显延长，FIB明显降低，差异有统计学意义（P〈0．01）；不同肝功能分级检测结果显示，A、B、C级之间，其PLT、MPV、PDW、PCT、PT、APTT、TT、FIB相互比较，差异有统计学意义（P〈0．01）。结论肝硬化患者存在血小板及凝血异常，血小板及其参数和凝血指标可作为临床判定肝硬化损害程度及预后的重要指标。

Study of platelet parameters and coagulation indices in 430 patients with hepatic cirrhosis

Objective To analyze the change of platelet parameters and coagulation indices in patients with hepatic cirrhosis, and the relation between the change and Child - Pugh score in hepatic cirrhosis. Methods In 430 patients with hepatic cirrhosis and 65 healthy people, the platelet and its parameters（ PLT,MPV,PDW ,PCT） were detected by KX - 21 N type auto counter, the coagulation indices （ PT, APTT, TT, FIB ） were detected by CA - 6000 type auto blood coagulation analyzer, the results were compared. Results Compared with healthy group, PLT,PCT descended evidently and MPV,PDW increased significantly, PT,APTT ,TT were longer and FIB descended evidently in patients with hepatic cirrhosis, there were significant difference between two groups（P 〈0. 01 ）. The PLT, MPV, PDW, PCT, PT, APTT, TT and FIB in the hepatic cirrhosis group had statistical significance followed by Child - Pugh score A to C （P 〈 0. 01 ）. Conclusion There is abnormality of platelet parameters and disturbance of blood co- agulation in patients with hepatic cirrhosis, the platelet parameters and coagulation indices help to determine the dam- age degree of hepatic cirrhosis and prognosis in hepatic cirrhosis.