缺血性肾病研究进展

随着人口老龄化,缺血性肾病（ischemic renal disease,IRD）已成为老年终末期肾病（end-stage renal disease,ESRD）的常见原因。其病因包括：肾动脉狭窄（RAS）、胆固醇栓塞、肾动脉血栓等。IRD的病理改变以肾小管损伤最常见,而临床表现以肾功能进行性减退为特征。目前临床上主要依据肾动脉狭窄合并肾功能不全做出IRD的诊断。肾动脉造影仍是确诊IRD的金指标。介入治疗、外科治疗和药物治疗是目前主要的治疗手段。

Ischemic renal disease

Ischemic renal disease（IRD）ultimately culminate in end-stage renal disease（ESRD）,and is usually the result of renal artery stenosis（RAS）,cholesterol embolism or renal artery thrombosis.Renal tubule impairment is the most common in the pathologic changes of IRD.Clinical feature indicative of IRD is the progressing renal insufficiency,and renal artery stenosis with renal insufficiency can strongly suggest IRD.The gold standard for diagnosis of ischemic renal disease is renal angiography.Interventions,surgery and medications can be beneficial.