大肠癌巨─微血管构筑的临床研究

为了探讨大肠癌和其间质血管的关系，我们研究了48例大肠癌标本不同部位的巨─-微血管构筑。方法：用癌瘤标本造影摄X线片、立体显微镜和微机图象定量分析。结果显示：癌中心血管稀疏或为无血管的坏死区及血管破坏；癌远近端瘤组织内血管增多增粗，畸形及紊乱；其血管定量参数与癌中心和癌远近端肠粘膜相比有显著差异（P＜O．05，P＜0．01）。结论：①大肠癌的发生发展依赖于血管形成和细胞增殖。②在理论上解释了大肠癌的临床病理过程。③大肠癌的恶性程度与其血管密度间似有负相关的趋势。④探讨了其临床应用价值。

Aclinical research on the macro-micro-vascular architecture of the large intestinal carcinoma

Objective:ln order to explore the relationship between the large intestinal carcinoma (LIC) and its stroma vascular architecture, We studied the macro-micro-vascular architecture of the specimens from48 cases of LIC in different areas. Methods:The angiox-ray technique. stereo--microscope and computerized image morphometrical analysis were used. Results: The blood vascular in the center area of the carcinoma showed sparse and avascular necrosis zone or vessel destruction, but in the distal and proximal ends of carcinoma, the vessels showed multiplying. increasing in width.malformation and inregularityl the vascular quantitative parameters were different significantly from those in carcinoma center area and in the distal and proximal ends of intestinal mucosa of the carcinoma (P< 0' 05 1 P< 0. 01 ). Conclusion: The results suggest: (1 ) The carcinogenesis and development of LIC depend on the abnormal neovascularization and unrestricted cell proliferation of the colorectal mucosa. (2) It explained the clinical pathological process of LIC. (3) The relationship between the vascular density and its maligmant grade of LIC had a tendency to negative correlation. (4) Its value in clinical applications were discussed.