抗环瓜氨酸肽抗体测定对类风湿关节炎诊断的临床价值

目的　分析评价抗环瓜氨酸肽抗体定量检测对类风湿关节炎的临床诊断价值以及结合类风湿因子测定的互补作用。方法　ELISA定量检测 5 0 6例血清样本抗环瓜氨酸肽抗体 ,散射免疫比浊法检测血清类风湿因子。结果　类风湿关节炎患者 2 0 3例 ,抗环瓜氨酸肽抗体阳性 16 6例 (81 8% ) ,平均浓度为 5 4 9RU ml。类风湿因子阳性 176例 (86 7% )。非类风湿关节炎患者 30 3例 ,抗环瓜氨酸肽抗体阳性 15例(4 9% ) ,类风湿因子阳性 6 8例 (2 2 4 % )。抗环瓜氨酸肽抗体特异性达 95 0 % ,敏感性 81 8%。结论　抗环瓜氨酸肽抗体对类风湿关节炎诊断的特异性很高 ,联合类风湿因子的检测明显地提高了类风湿关节炎早期诊断的准确性。

Determination of anti-cyclic citrullinated peptide antibody for the diagnosis of rheumatoid arthritis

Objective To analyze and evaluate the clinical diagnosis significance of anti-cyclic citrullinated peptide (anti-CCP) antibody in patients with rheumatoid arthritis (RA) and its complementary effect combining with rheumatoid factor (RF).Methods Anti-CCP antibody in 506 serous samples was detected by quantitative ELISA and rheumatoid factor by BNP nephelometer. Results Among the 203 patients with RA, 166 (81.8%) were detected positive for anti-CCP antibody with the mean concentration of 54.9 RU/ml and 176 (86.7%)positive for rheumatoid factors; while in 303 patients without RA, only 15 (4.9%) were positive for anti-CCP antibody and 68 (22.4%) positive for rheumatoid factors. The sensitivity of anti-CCP antibody was 81.8% and specificity, 95.0%.Conclusion The measurements of anti-CCP antibody and rheumatoid factor will remarkably improve the accuracy of early diagnosis of RA.