复方茵虎汤对实验性肝损伤的保护作用

目的：本实验研究复方茵虎汤（复方茵虎汤）对四氯化碳致小鼠肝损伤的保护作用。方法：以腹腔注射四氯化碳（CCl4）建立小鼠肝损伤模型，以复方茵虎汤作为受试药物，以联苯双酯作为阳性对照药物，以肝指数（LJI）、血清中谷氨酸氨基转移酶（ALT）、天冬氨酸转氨酶（AST）、肝组织匀浆中超氧化物歧化酶（SOD）和丙二醛（MDA）水平为检测指标，观察复方茵虎汤对肝损伤的保护作用。结果：复方茵虎汤能够明显降低CCl4致小鼠肝损伤血清中ALT和AST水平，升高肝组织中SOD水平，降低肝组织中MDA水平，减轻四氯化碳对肝脏细胞的病理损伤。结论：复方茵虎汤对CCl4致小鼠急性肝损伤有一定的保护作用。

Protective effect of compound Yinhu decoction on experimental liver injury

Objective: To observe the protective effect of Compound Yinhu decoction on acute liver injury induced by carbon tetrachloride(CCl₄) in mice.Methods: Acute liver injury was established by intraperitoneal injection of CCl₄.Compound Yinhu decotion was tested as subjects drug and bifendate as a positive control drug.The liver index(LI),the levels of serum alanine amino-transferase(ALT) and aspartate amino-transferase(AST),the superoxide dismutase(SOD) and molondialdehyde(MDA) levels in the liver tissue were measured and the protective effect of Compound Yinhu decotion on liver injury was observed.Results:Compound Yinhu decotion could significantly reduce serum ALT and AST levels,increase liver SOD level and decrease liver MDA level.It could also reduce the liver cell morphological injury.Conclusions:Compound Yinhu decotion has some protective effect on acute liver injury induced by CCl₄ in mice.