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煤尘在大鼠肺中清除途径的电镜观察
引用本文:陈善湘 孔润莲. 煤尘在大鼠肺中清除途径的电镜观察[J]. 工业卫生与职业病, 1991, 17(3): 133-136
作者姓名:陈善湘 孔润莲
作者单位:华北煤炭医学院组胚教研室,华北煤炭医学院组胚教研室 河北唐山市建设路 063000,河北唐山市建设路 063000
摘    要:
本文报道给大鼠肺内一次性灌注煤尘生理盐水混悬液,用电镜观察煤尘在肺内被转运和排出的途径。进入肺泡腔的煤尘颗粒主要由肺泡巨噬细胞(AM)吞噬并沿气道上行排出体外;一少部分煤尘颗粒还可由I型肺泡上皮细胞以胞吞的方式转运到肺间质,再由间质中的巨噬细胞吞噬并穿越内皮进入毛细血管、由血液带出肺外。

关 键 词:煤尘 肺泡 巨噬细胞

THE CLEARANCE PATHWAYS OF COAL DUSTS IN RAT LUNG
Chen Shanxiang Kong Runlia. THE CLEARANCE PATHWAYS OF COAL DUSTS IN RAT LUNG[J]. Industrial Health and Occupational Diseases, 1991, 17(3): 133-136
Authors:Chen Shanxiang Kong Runlia
Abstract:
After perfusing one-shot the mixed fluid of coal dusts and saline solution into rat's lung,the clearance pathways of coal dasta in lung was observed by electron microscopy.The results indicated that the coal dusts in alveolar lumen were mainly engulfed by alveolar macrophages and transferred upward along the airways to extrapulmonary sites.In addition to that,a fraction of coal dusts in alveoli might eater the type I epithelied cell by endocytosis and came out from the type I cell by exocytosis to the pulmonary interstitium.The coal dusts in the pulmonary interstitium were engulfed by pulmonary macrophages and penetrated through the capillary wall.Finally the coal dusts in macrophages were transferred to extrapulmonary sites by the blood.
Keywords:coal dust  lung  alveolar macrophages
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