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| 免疫相关性血细胞减少症41例临床分析 | |
| 引用本文： | 陆沭华,张彦明,孙雨梅,何广胜,崔红霞,赵广圣,张兴霞. 免疫相关性血细胞减少症41例临床分析[J]. 临床血液学杂志, 2010, 0(2) |
| 作者姓名： | 陆沭华 张彦明 孙雨梅 何广胜 崔红霞 赵广圣 张兴霞 |
| 作者单位： | 徐州医学院附属淮安医院江苏淮安市第二人民医院血液科;苏州大学附属第一医院血液科; |
| 摘 要： | 目的:观察41例免疫相关性血细胞减少(immunorelated hemocytopenia,IRH)或全血细胞减少症(immunorelated pancytopenia,IRP)患者的临床特点,以提高对本病的认识。方法:分析41例IRH/IRP患者临床表现、血常规、骨髓象、骨髓单个核细胞抗人球蛋白(BMMNC-Coombs)试验、抗核抗体ANA和ENA抗体谱、T淋巴细胞亚群、染色体核型等以及对肾上腺糖皮质激素、环孢素A等免疫抑制剂的治疗反应。结果:本组病例临床主要表现为贫血、出血、感染;血常规呈三系、二系或一系减少,网织红细胞百分比不低;骨髓增生以活跃或明显活跃为主(82.9%),红系比例多增高;BMMNC-Coombs试验阳性率78.0%;除外了再生障碍性贫血(AA)、骨髓增生异常综合征(MDS)、阵发性睡眠性血红蛋白尿(PNH)等疾病;小部分病例(19.5%)并发系统性红斑狼疮(SLE)等自身免疫性疾病;对肾上腺糖皮质激素、环孢素A等治疗有良好反应。结论:IRH/IRP是由于T淋巴细胞调控异常致B淋巴细胞产生针对骨髓未成熟造血细胞的自身抗体而使血细胞减少,BMMNC-Coombs试验对IRH/IRP的... |
| 关 键 词： | 血细胞减少 自身免疫 骨髓单个核细胞 抗人球蛋白试验 |
Clinical analysis of 41 patients with immune related hematocytopenia |
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| LU Shuhua ZHANG Yanming SUN Yumei HE GuangshengCUI Hongxia ZHAO Guangsheng ZHANG Xingxia. Clinical analysis of 41 patients with immune related hematocytopenia[J]. Journal of Clinical Hematology, 2010, 0(2) | |
| Authors: | LU Shuhua ZHANG Yanming SUN Yumei HE GuangshengCUI Hongxia ZHAO Guangsheng ZHANG Xingxia |
| Affiliation: | 1Department of Hematology/a>;Second People Hospital of Huaian City/a>;Huaian/a>;223002/a>;China/a>;2Department of Hematology/a>;First Affiliated Hospital of Suzhou University |
| Abstract: | Objective:To improve the recognition of immune related hematocytopenia (IRH) or immune related pancytopenia (IRP) by observing clinical features of 41 patients with IRH/IRP.Method:Blood routine,bone marrow morphology,bone marrow mononuclear cell (BMMNC) antiglobulin test (Coombs test),antinuclear antibody ANA and ENA,subsets of T lymphocyte,chromosome analysis et al were performed in 41 cases of IRH/IRP/. Clinical features and responses to glucocorticoid,cyclosporin A were analyzed. Result:The clinical mani... |
| Keywords: | hematocytopenia autoimmunity bone marrow mononuclear cell antiglobulin test |
| 本文献已被 CNKI 等数据库收录！ | |