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| HBeAg阴性的慢性HBV感染者乙肝病毒前C区G1896A变异分析 | |
| 引用本文： | 张委,江培学,康熙雄. HBeAg阴性的慢性HBV感染者乙肝病毒前C区G1896A变异分析[J]. 中国卫生检验杂志, 2011, 0(9) |
| 作者姓名： | 张委 江培学 康熙雄 |
| 作者单位： | 北京市海淀医院检验科;上海复星医学科技发展有限公司;首都医科大学北京天坛医院; |
| 摘 要： | 目的:了解HBeAg阴性的慢性HBV感染者乙肝病毒前C区G1896A变异情况,为临床乙肝诊治提供科学依据。方法:北京市海淀医院HBeAg阴性的慢性HBV感染者496例,其中HBeAg阴性慢性乙型肝炎患者380例,非活动期HBV感染者196例,取血液及肝组织样本进行HBV血清学标志检测(HBsAg、抗-HBs、HBeAg、抗-HBe和抗-HBc)、丙氨酸谷丙转移酶(ALT)、HBV DNA定量检测;HBV前C区G1896A变异检测;肝组织学检查;采用SPSS13.0软件进行数据分析。结果:两组患者血清中均检测到HBV DNA,其中HBeAg阴性慢性乙型肝炎患者组检出率100%(296/296),平均值为4.90±1.49log10拷贝数/毫升,非活动期HBV感染者组检出率42.0%(84/200)平均值为3.22±0.59 log10拷贝数/毫升,两组比较HBV DNA载量差异有显著性;在HBV DNA载量>1000拷贝/ml的病例中HBeAg阴性慢性乙型肝炎组的乙肝病毒存在前C区G1896A变异,发生率为83.8%(248/296),非活动期HBV感染组乙肝病毒前C区G1896A也存在变异,发生率为33.3%... |
| 关 键 词： | 乙型肝炎病毒 前C区 G1896A变异 |
Analysis of hepatitis B virus pre-C G1896A mutation in person with BeAg-negative chronic HBV infection |
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| ZHANG Wei,JIANG Pei-xue,KANG Xi-xiong. Analysis of hepatitis B virus pre-C G1896A mutation in person with BeAg-negative chronic HBV infection[J]. Chinses Journal of Health Laboratory Technology, 2011, 0(9) | |
| Authors: | ZHANG Wei JIANG Pei-xue KANG Xi-xiong |
| Affiliation: | ZHANG Wei1,JIANG Pei-xue2,KANG Xi-xiong3(1.Beijing Haidian Hospital Laboratory,Beijing 100080,China,2.Shanghai Fosun Medical Technology Development Co.,Ltd,Shanghai,200233,3.Beijing Tiantan Hospital Affiliated to Capital Medical University,Beijing 100050,China) |
| Abstract: | Objective: To understand hepatitis B virus pre-C G1896A mutation in the HBeAg-negative chronic HBV infection patients and provide scientific basis for clinical treatment of hepatitis B.Methods: 496 cases of HBeAg-negative chronic HBV infection,including 380 cases with HBeAg-negative chronic hepatitis B and 196 cases of non-active HBV infection were selected as test samples.Blood and liver tissue samples were conducted serological diagnosis of HBV infection(HBsAg,anti-HBs,HBeAg,anti-HBe and anti-HBc),alanine... |
| Keywords: | Hepatitis B virus Pre-C G1896A mutation |
| 本文献已被 CNKI 等数据库收录！ | |