| e抗原阴性慢性乙型肝炎患者血清HBV-DNA载量与HBsAg以及AST含量的关系研究 |
| |
| 引用本文： | 郑专,杨俊杰. e抗原阴性慢性乙型肝炎患者血清HBV-DNA载量与HBsAg以及AST含量的关系研究[J]. 中国卫生检验杂志, 2011, 0(10) |
| |
| 作者姓名： | 郑专 杨俊杰 |
| |
| 作者单位： | 浙江省绍兴市人民医院分子医学中心;温州医学院; |
| |
| 摘 要： | 目的:研究e抗原阴性慢性乙型肝炎患者外周血中HBV-DNA载量与乙型肝炎病毒表面抗原(HBsAg)以及反映肝脏损伤水平的肝功能指标天冬氨酸氨基转移酶(AST)含量的关系。方法:收集238例e抗原阴性慢性乙肝患者血清,采用荧光定量PCR法(FQ-PCR)检测HBV-DNA载量,利用时间分辨免疫荧光法(TRFIA)检测乙肝表面抗原的浓度,使用全自动生化仪检测AST水平;最后,利用SPSS软件做统计分析。结果:HBV-DNA载量与HBsAg含量有一定的相关性(r=0.21,P<0.01);与AST水平经相关性分析无统计学意义;在AST异常情况下,HBV-DNA载量与HBsAg的相关性更佳(r=0.362,P<0.01)。结论:e抗原阴性慢性乙型肝炎患者血清中HBV-DNA载量与HBsAg定量水平有相关性。
|
| 关 键 词： | 慢性乙型肝炎 乙肝病毒核酸 天冬氨酸氨基转移酶 乙型肝炎病毒表面抗原 |
Relationship among HBV-DNA,HBsAg and aspartate aminotransferase levels in chronic hepatitis B patients with e antigen negative |
| |
| ZHENG Zhuan,YANG Jun-jie. Relationship among HBV-DNA,HBsAg and aspartate aminotransferase levels in chronic hepatitis B patients with e antigen negative[J]. Chinses Journal of Health Laboratory Technology, 2011, 0(10) |
| |
| Authors: | ZHENG Zhuan YANG Jun-jie |
| |
| Affiliation: | ZHENG Zhuan1,YANG Jun-jie2 |
| |
| Abstract: | Objective:To study the relationship among hepatitis B virus DNA(HBV-DNA),HBsAg and aspartate aminotransferase(AST) levels in chronic hepatitis B patients with e antigen negative.Methods: HBV-DNA,HBsAg and AST levels of 238 chronic hepatitis B patients with e antigen negative were detected by realtime-PCR,time-resolved immunofluorometric assay(TRFIA) and auto biochemistry analyzer respectively.The data was analyzed by SPSS software.Results: There was some correlation(r=0.21,P<0.01) between HBV-DNA and HBsAg ... |
| |
| Keywords: | Chronic hepatitis B Hepatitis B virus DNA Aspartate aminotransferase Hepatitis B surface antigen |
| 本文献已被 CNKI 等数据库收录！ |
