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The fibrinolytic system facilitates tumor cell migration across the blood-brain barrier in experimental melanoma brain metastasis
Authors:George Perides   Yuzheng Zhuge   Tina Lin   Monique F Stins   Roderick T Bronson  Julian K Wu
Affiliation:(1) Department of Surgery, Division of Neurosurgery, Beth Israel Deaconess Medical Center, Harvard Medical School, and Department of Surgery, Tufts-New England Medical Center, Tufts University School of Medicine, Boston, MA, USA;(2) Department of Surgery, Division of Neurosurgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA;(3) Department of Surgery, Division of Neurosurgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA;(4) The Johns Hopkins University School of Medicine, Baltimore, MD, USA;(5) Dana-Farber-Harvard Cancer Center, Harvard Medical, Boston, MA, USA;(6) Department of Surgery, Division of Neurosurgery, Beth Israel Deaconess Medical Center, Harvard Medical School, and Department of Neurosurgery, Tufts-New England Medical Center, Tufts University School of Medicine, Boston, MA, USA
Abstract:

Background  

Patients with metastatic tumors to the brain have a very poor prognosis. Increased metastatic potential has been associated with the fibrinolytic system. We investigated the role of the fibrinolytic enzyme plasmin in tumor cell migration across brain endothelial cells and growth of brain metastases in an experimental metastatic melanoma model.
Keywords:
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