血清胎盘生长因子与冠状动脉侧支循环的关系

目的探讨冠状动脉粥样硬化性心脏病(以下简称冠心病,CHD)患者血清胎盘生长因子(placental growth factor,PlGF)浓度与冠状动脉侧支形成的关系。方法根据冠状动脉造影结果入选78例冠状动脉严重狭窄的CHD患者,按Rentrop方法进行冠状动脉侧支分级:0级(23例),1级(23例),2级(18例),3级(14例),采用酶联免疫法检测患者血清PlGF浓度。结果冠状动脉侧支为0级、1级患者的PlGF血清水平均明显低于冠状动脉侧支为2、3级组患者(P<0.01);冠状动脉侧支分级与PlGF血清水平呈明显正相关(r=0.534,P<0.01)。结论在严重的CHD患者中,PlGF血清浓度与冠状动脉侧支分级呈明显正相关,提示PlGF可能有促进冠状动脉侧支循环形成的作用。

Relationship between serum placental growth factor and coronary collateral circulation

Objective To investigate the relation between serum placental growth factor(PlGF) level and coronary collateral circulation(CCC) in patients with coronary artery disease. Methods A total of 78 patients with coronary artery disease(CAD) with severe coronary stenosis were included according to coronary angiography, CCC severities were divided into the following 4 degrees: degree 0(n=23), degree 1(n=23), degree 2(n=18), degree 3(n=14) by Rentrop method. Serum concentration of PlGF was measured by enzyme-linked immunosorbent assay(ELISA). Results Serum PlGF level in patients with CCC degree 0 and 1 was decreased as compared with that in CCC degree 2 and 3(P<0.01). The CCC degrees had a significant positive correlation with serum levels of PlGF(r=0.534, P<0.01). Conclusion In severe coronary artery disease, serum concentration of PlGF showed a significant positive correlation with coronary collateral circulation, suggesting that PlGF may be a factor that can enhance coronary collateral circulation.