| 氩氦冷冻消融治疗进展期肝癌的疗效及其影响因素研究 |
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| 引用本文： | 常秀娟,陆荫英,白文林,陈艳,安林静,周霖,吴煜,王鋐,楼敏,苏淑慧,杨永平.氩氦冷冻消融治疗进展期肝癌的疗效及其影响因素研究[J].肝脏,2010,15(1):11-14. |
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| 作者姓名： | 常秀娟 陆荫英 白文林 陈艳 安林静 周霖 吴煜 王鋐 楼敏 苏淑慧 杨永平 |
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| 作者单位： | 1. 100039,北京,解放军军事医学科学院;解放军第三○二医院肝癌治疗研究中心
2. 解放军第三○二医院肝癌治疗研究中心 |
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| 基金项目： | 国家重大专项基金资助项目，军队医学杰出人才基金资助项目 |
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| 摘 要： | 目的探讨氩氦冷冻消融治疗乙型肝炎相关性进展期肝细胞癌(HCC)的临床疗效和影响生存期的因素。方法采用临床列队对照研究190例乙型肝炎相关性进展期HCC患者,其中147例行氩氦冷冻消融治疗,43例未行局部消融和肝动脉化疗栓塞治疗。结果氩氦冷冻消融乙型肝炎相关性进展期HCC患者生存期为10.11个月,未治疗者生存期仅为4.73个月,氩氦冷冻消融治疗进展期HCC严重肝损伤发生率为5.4%,Child-Pugh分级≥B8的病例占87.5%,胆红素水平51.3μmol/L者占75%;在HBV相关性进展期HCC中,HBV DNA载量中、低水平占91%,HBeAg阴性患者占66.67%,两者与肿瘤细胞分化程度无关;肝硬化程度及肿瘤细胞分化程度是影响进展期HCC患者生存期的关键因素。结论冷冻消融治疗乙型肝炎相关性进展期HCC能显著延长患者的生存期,是影响进展期HCC生存期的独立因素;Child-Pugh分级≥B8,伴有胆红素水平51.3μmol/L的进展期HCC患者不适宜行冷冻消融;肝硬化程度及肿瘤细胞分化程度是影响进展期HCC患者生存期的关键因素。
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| 关 键 词： | 氩氦冷冻消融 慢性乙型肝炎 进展期肝细胞癌 生存期 |
Clinical effect and survival time of argon-helium cryoablation for hepatitis B-related advanced hepatocellular carcinoma:a pilot clinical study |
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| CHANG Xiu-juan,LU Yin-ying,BAI Wen-lin,CHEN Yan,AN Lin-jing,ZHOU Lin,WU Yu,WANG Hong,LOU Min,SU Shu-hui,YANG Yong-ping.Clinical effect and survival time of argon-helium cryoablation for hepatitis B-related advanced hepatocellular carcinoma:a pilot clinical study[J].Chinese Hepatology,2010,15(1):11-14. |
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| Authors: | CHANG Xiu-juan LU Yin-ying BAI Wen-lin CHEN Yan AN Lin-jing ZHOU Lin WU Yu WANG Hong LOU Min SU Shu-hui YANG Yong-ping |
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| Institution: | CHANG Xiu-juan,LU Yin-ying,BAI Wen-lin,CHEN Yan,AN Lin-jing,ZHOU Lin,WU Yu,WANG Hong,LOU Min,SU Shu-hui,YANG Yong-ping.Center of Therapeutic Research for Hepatocellular Carcinoma,302 Hospital of PLA,Beijing 100039,China |
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| Abstract: | Objective To evaluate the clinical effect and the survival time of percutaneous argon-helium cryoablation for hepatitis B-related advanced hepatocellular cancer.Methods One hundred and ninty patients(147 patients with cryoablated,43 patients without any ablation) with hepatitis B-related HCC were studied by means of clinical cohort.Results The survival time of patients with hepatitis B-related advanced HCC received cryoablation was 10.11 months.On the contrary the survival time was 4.73 months.The rate of t... |
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| Keywords: | Cryoablation Chronic hepatitis B Advance hepatocellular carcinoma Over of survivial time |
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