金刚烷胺、甲基多巴及其两药合用抗吗啡依赖大鼠催促戒断症状的机制初步探讨

目的 了解金刚烷胺(以下简称G)、甲基多巴(以下简称D)及两药对吗啡依赖动物尾状核-纹状体多巴胺受体(DAR)和腺苷酸环化酶(AC)活性的影响.方法 用吗啡依赖大鼠模型观察G、D和G D对其尾状核-纹状体DAR和AC活性的影响.结果 G25mg/kg可上调吗啡依赖大鼠尾状核-纹状体DAR数量,对其亲和力影响不大,对AC活性无影响,D50mg/kg可抑制吗啡依赖大鼠尾状核-纹状体的AC活性,对DAR影响不大;两药合用可上调吗啡依赖大鼠尾状核-纹状体DAR数量,抑制AC活性.结论 D及G、D合用可以上调尾状核-纹状体的DAR数量、抑制AC活性.

Symmetrel,dopamet and combination use of two drugs and initial probe into effect and mechanism on hastening abstinence symptom of anti morphine addict animals

Objective To understand the therapeutic action of the symmetrel(G),dopamet(D) and the combined use of the two drugs on hastening abstinence symptom of the morphine addict animals and the effect on caudate nucleus-corpus striatum dopamine receptor(DAR)and adenylate cyclase(AC) activity of the morphine addict animals.Methods Using the morphine addict rats as the model to observe the effect of the G,D and G D on the caudate nucleus-corpus striatum DAR and AC activity.Results G25mg/kg increased the amount of caudate nucleus-corpus striatum DAR of the morphine addict rats and showed little effect on the affinity and no effect on the AC activity.D50mg/kg suppressed the AC activity of the caudate nucleus-corpus striatum of the morphine addict rats and showed little effect on DAR;the combination use of the two drugs can increase the DAR amount of caudate nucleus-corpus striatum of the morphine addict rats and suppress the AC activity.Conclusion The combined use of G and D showed a certain synergism,thereinto the combined use of low dosage of G and high dosage of D can take the best effect.The mechanism of action is possibly related to the increase of the DAR amount of caudate nucleus-corpus striatum and the suppression of AC activity.