| 人肝癌细胞膜上HSP70的表达 |
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| 引用本文： | 郭建巍,蔡美英,邵宝妹,赵燕,魏大鹏. 人肝癌细胞膜上HSP70的表达[J]. 临床肝胆病杂志, 2001, 17(2): 105-106 |
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| 作者姓名： | 郭建巍 蔡美英 邵宝妹 赵燕 魏大鹏 |
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| 作者单位： | 华西医科大学免疫学教研室,四川,成都,610041;华西医科大学免疫学教研室,四川,成都,610041;华西医科大学免疫学教研室,四川,成都,610041;华西医科大学免疫学教研室,四川,成都,610041;华西医科大学免疫学教研室,四川,成都,610041 |
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| 摘 要： | 用流式细胞仪和Cell-ELISA检测了 4株人肝癌细胞膜上HSP70的表达。结果表明正常情况下人肝癌细胞膜上HSP70的表达较低 ,经热处理后表达增加 (P <0 0 1)并显示出细胞之间的差异 (P <0 0 1)。推测其低表达可能与肝癌细胞逃逸机体免疫监视有关 ,对制定肝癌的防治对策有重要的指导意义。
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| 关 键 词： | 肝癌细胞 热休克蛋白70 |
| 文章编号： | 1001-5256(2001)02-0105-02 |
| 修稿时间： | 2000-05-24 |
Detection of HSP70 expression on the membrane of human Hepatocellular carcinoma cell lines |
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| GUO Jian-wei,CAI Mei-ying,SHAO Bao-mei,et al.. Detection of HSP70 expression on the membrane of human Hepatocellular carcinoma cell lines[J]. Chinese Journal of Clinical Hepatology, 2001, 17(2): 105-106 |
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| Authors: | GUO Jian-wei CAI Mei-ying SHAO Bao-mei et al. |
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| Affiliation: | GUO Jian-wei,CAI Mei-ying,SHAO Bao-mei,et al. Department of immunology,West China university of medical sciences. Chengdu 610041 |
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| Abstract: | The Expression of HSP70 on the membrane of human Hepatocellular carcinoma cell lines (QGY-7703, SMMC-7721, HEPG-2, Alexander) was detected by flow cytometric analysis and Gell-ELISA method. Results show that under the physiological condition the Expression of HSP70 on 4 strains were lower than that treated with heat (P<0.01) and there were differences between QGY-7703 and other strains. This suggests that hepatocellular carcinoma cell lines escape from immune surveillance may be related with its low membrane HSP70 expression. |
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| Keywords: | Hepatocellular carcinoma cell lines Heat shock protein 70 |
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