Affiliation: | ∗ Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts;† Alnylam Pharmaceuticals, Cambridge, Massachusetts;‡ David H. Koch Institute for Integrative Cancer Research, Department of Chemical Engineering, Division of Health Science Technology, and Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts;§ Cardiovascular Division, Department of Medicine, Brigham and Women''s Hospital, Boston, Massachusetts;‖ Department of Systems Biology, Harvard Medical School, Boston, Massachusetts |