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In Vivo Silencing of the Transcription Factor IRF5 Reprograms the Macrophage Phenotype and Improves Infarct Healing
Authors:Gabriel Courties  Timo Heidt  Matthew Sebas  Yoshiko Iwamoto  Derrick Jeon  Jessica Truelove  Benoit Tricot  Greg Wojtkiewicz  Partha Dutta  Hendrik B. Sager  Anna Borodovsky  Tatiana Novobrantseva  Boris Klebanov  Kevin Fitzgerald  Daniel G. Anderson  Peter Libby  Filip K. Swirski  Ralph Weissleder  Matthias Nahrendorf
Affiliation: Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Alnylam Pharmaceuticals, Cambridge, Massachusetts; David H. Koch Institute for Integrative Cancer Research, Department of Chemical Engineering, Division of Health Science Technology, and Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts;§ Cardiovascular Division, Department of Medicine, Brigham and Women''s Hospital, Boston, Massachusetts; Department of Systems Biology, Harvard Medical School, Boston, Massachusetts
Abstract:
Keywords:IRF5   healing   heart failure   macrophage   myocardial   infarction
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