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| 表皮生长因子对TPN大鼠肠粘膜机械屏障的影响 | |
| 引用本文： | 赖俊浩 王俊义. 表皮生长因子对TPN大鼠肠粘膜机械屏障的影响[J]. 肠外与肠内营养, 1997, 4(4): 213-215 |
| 作者姓名： | 赖俊浩 王俊义 |
| 作者单位： | [1]解放军第三陆军医院普外科 [2]第四军医大学西京医院胃肠外科 |
| 摘 要： | 本文旨在探讨表皮生长因子（ＥＧＦ）对ＴＰＮ大鼠小肠粘膜机械屏障的保护作用。将４８只ＳＤ大鼠随机分为正常对照组、ＴＰＮ组以及ＴＰＮ－ＥＧＦ组。结果显示ＴＰＮ组大鼠小肠绒毛面积、高度、隐窝深度、隐窝细胞数及有丝分裂指数均较对照组明显降低（Ｐ〈０．０１）；ＴＰＮ－ＥＧＦ组与对照组比较无显著差异（Ｐ〉０．０５）。提示外源性补充ＥＧＦ能促进ＴＰＮ大鼠隐窝细胞增殖，恢复隐窝细胞生成率，从而达到保护肠粘膜机械屏 |
| 关 键 词： | 胃肠外营养 表皮生长因子 肠粘膜 |
Effects of epidermal growth factor on intestinal cellular barrier of TPN rats |
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| Lai Junhao,Wang Junyi,Zhang Guoxiang Departmentof Gastroenterological Surgery,Third Military H ospital of PL A. Effects of epidermal growth factor on intestinal cellular barrier of TPN rats[J]. Parenteral & Enteral Nutrition, 1997, 4(4): 213-215 | |
| Authors: | Lai Junhao Wang Junyi Zhang Guoxiang Departmentof Gastroenterological Surgery Third Military H ospital of PL A |
| Abstract: | The experiment was designed to investigate the effects of infused exogenous EGF on intestinal cellular barrier of TPN rats.Fourty- eight Sprague Dowley rats were randomized to three groups:control group(n=1 6 ) ,TPN group (n=1 6 ) and TPN- EGF group (n=1 6 ) .The results showed that the villus area,villus height,crypt depth,crypt cell population and mitotic index was reduced(P<0 .0 1 ) in TPN rats and was restored to normal levels when EGF was administed(P>0 .0 5 ) .From this study,we conclude that infused exgenous EGFcan stimulate the crypt cell proliferation,restore the crypt cell production rate,and protect the intestinal cellular barrier from atrophia of TPN rats. |
| Keywords: | Epidermal growth factor Total parenteral nutrition Intestine |
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