血管内皮生长因子及转化生长因子-β联合检测在老年结核性与恶性胸腔积液中的价值

目的 监测老年结核性胸腔积液和老年恶性胸腔积液中血管内皮生长因子（VEGF）和转化生长因子-β（TGF-β）在鉴别老年结核性和老年恶性胸腔积液中的价值。方法 老年结核性胸腔积液组31例，老年恶性胸腔积液组30例，分别行胸腔闭式引流术。采用酶联免疫吸附法（ELISA）法检测2组患者的胸液中VEGF及TGF-β的水平。结果 恶性胸腔积液中VEGF及TGF-β的水平呈正相关（r=0．438，P〈0．05）。恶性胸腔积液中VEGF及TGF-β水平[（269±62）ng／L，（125．5±12．0）mg／L]较结核性胸腔积液[（104±55）ng／L，（81±23）mg／L]升高，差异有统计学意义（P〈0．05）。结论 VEGF及TGF-β在老年恶性胸腔积液的形成起重要作用，对恶性胸腔积液与结核性胸腔积液的鉴别具有重要价值。

Value of vascular endothelial growth factor and transforming growth factor-β levels in chest fluid of older patients with malignancy and tuberculosis

Objective To investigate the function of vascular endothelial growth factor （VEGF） and transforming growth factor-β（TGF-β）levels in the pleural fluid of older patients with malignancy and tuberculosis. Methods The levels of VEGF and TGF-β in pleural fluid of 61 older patients were measured by enzyme-linked immunosorbent assay （ELISA）method. Results There was significantly positive correlation between the levels of VEGF and TGF-β in the pleural fluid of patients with malignant pleural effusions （r = 0. 438, P 〈 0. 05）. The levels of VEGF and TGF-β （269 ± 62 ng/L,125 ± 8. 1 mg/L） were significantly higher in the pleural fluid of patients with malignant pleural effusions group than those in tuberculosis group（104 ±55 mg/L,85 ± 12.0 mg/L） （P 〈0.05）. Conelusious These findings suggest that VEGF,TGF-β are significant to the patient with malignant chest fluid and then may play an important role in differentiation of it from tuberculosis.