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A HhaI/BstUI polymorphism in a novel gene at human chromosome 11p15.5
Authors:Kiyonori Miura  Hideaki Masuzaki  Tadayuki Ishimaru  Norio Niikawa  Y. Jinno
Affiliation:(1) Department of Human Genetics, Nagasaki University School of Medicine, 1-12-4 Sakamoto, Nagasaki, 852-8523 Japan Tel. +81-95-849-7176; Fax +81-95-849-7121 e-mail: siriusyj@net.nagasaki-u.ac.jp, JP;(2) Department of Obstetrics and Gynecology, Nagasaki University School of Medicine, Nagasaki, Japan, JP
Abstract:We found a HhaI/BstUI polymorphism in the 3′ untranslated region of a novel gene which was localized to 11p15.5. This region is one of prominent imprinting domains and contains multiple imprinted genes, such as H19, IGF2 , KVLQT1, and p57 KIP2 , which suggests that regional factors might contribute to the imprinting. This polymorphism will be useful in the allelic analysis of expression and methylation of the novel gene. Received: July 24, 1998 / Accepted: July 29, 1998
Keywords:Imprinting  11p15.5  polymorphism  PCR-RFLP
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