| 脑恶性胶质瘤经动脉超选化疗的初步观察 |
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| 引用本文： | 王来兴,刘建民,赵瑞,岳志健,周晓平,杨鹏飞,于云龙.脑恶性胶质瘤经动脉超选化疗的初步观察[J].中国微侵袭神经外科杂志,2011,16(8):337-339. |
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| 作者姓名： | 王来兴 刘建民 赵瑞 岳志健 周晓平 杨鹏飞 于云龙 |
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| 作者单位： | 1. 第二军医大学附属长海医院神经外科,上海,200433
2. 解放军107医院神经外科,烟台,264002 |
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| 基金项目： | 上海市科委重点科技攻关资助项目(编号:08411953600) |
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| 摘 要： | 目的观察脑恶性胶质瘤采用尼莫司汀经动脉超选化疗的疗效及安全性。方法回顾性分析64例脑恶性胶质瘤病人的临床资料,其中多形性胶质母细胞瘤38例,间变性星形细胞瘤22例,胶质肉瘤4例。显微镜下尽量切除肿瘤,术后采用尼莫司汀(2.5 mg/kg)行经动脉超选化疗。结果肿瘤全切除56例,大部分切除6例,部分切除2例。所有病例随访3～18个月,平均8个月。术后复发8例(12.50%),其中再次手术2例。化疗前后KPS评分差异无统计学意义(P>0.05)。出现不同程度骨髓抑制40例(62.50%);胃肠道反应4例(6.25%);未见与介入操作相关的并发症、肝肾功能改变、眼部及神经系统并发症。结论脑恶性胶质瘤采用尼莫司汀经动脉超选化疗是一种安全、有效的辅助治疗方法,值得进一步研究。
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| 关 键 词： | 神经胶质瘤 化疗 超选择性 动脉内灌注 |
Intra-arterial superselective chemotherapy for malignant brain glioma:a preliminary observation |
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| Wang Laixing,Liu Jianmin,Zhao Rui,Yue Zhijian,Zhou Xiaoping,Yang Pengfei,Yu Yunlong.Intra-arterial superselective chemotherapy for malignant brain glioma:a preliminary observation[J].Chinese Journal of Minimally Invasive Neurosurgery,2011,16(8):337-339. |
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| Authors: | Wang Laixing Liu Jianmin Zhao Rui Yue Zhijian Zhou Xiaoping Yang Pengfei Yu Yunlong |
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| Institution: | Wang Laixing1,Liu Jianmin1,Zhao Rui1,Yue Zhijian1,Zhou Xiaoping1,Yang Pengfei1,Yu Yunlong2 1.Department of Neurosurgery,Changhai Hospital,Second Military Medical University,Shanghai 200433,China,2.Department of Neurosurgery,107 Hospital of PLA,Yantai,Shandong 264002 |
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| Abstract: | Objective To observe therapeutic efficacy and safety of intra-arterial superselective chemotherapy with nimustine in the treatment of malignant brain glioma.Methods The clinical data of 64 patients with malignant brain glioma,including 38 with glioblastoma multiforme,22 with anaplastic astrocytoma and 4 with gliosarcoma,were analyzed retrospectively.All the patients underwent intra-arterial superselective chemotherapy with nimustine(2.5mg/kg) after the resection of tumor under the microscope.Results Total r... |
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| Keywords: | glioma chemotherapy superselective intra-arterial infusion |
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