心复康对心肌梗死大鼠心室重塑和功能的影响

[目的]观察中药心复康对大鼠心肌梗死心室重塑参数和心功能的影响,探讨中药对心室重塑的保护作用。[方法]采用冠状动脉结扎法制作心肌梗死模型,术后随机分为假手术组、模型组、中药高剂量组和中剂量组,每组12只。中药高剂量(每天81g/kg)和中剂量组(每天40.5g/kg)给予中药心复康水煎剂灌胃,假手术组和模型组每天等量生理盐水灌胃。28d后,处死动物之前行心脏超声心动图观察心脏功能;称量体质量;称量肺的相对质量;病理切片观察心脏微观结构改变。[结果]中药高剂量组左室舒张末期内径(LVDd),左室收缩末期内径(LVDs),舒张末期室间隔厚度(IVSd),收缩末期室间隔厚度(IVSs),舒张末期左室后壁厚度(LVPWd),收缩末期左室后壁厚度(LVPWs),射血分数(EF),每分钟排出量(CO),左室短轴缩短率(FS),与模型组比较均有统计学意义。模型组与各组比较胶原纤维增多,排列紊乱。[结论]中药可以改善心室重塑大鼠的心功能,保护心脏结构重整;抑制心脏胶原纤维的增生。

Effect of Xinfukang on left ventricular remodeling and function after myocardial infarction in rats

[Objective] To study the impact of Xinfukang on left ventricular remodeling (LVRM) and cardiac function after myocardial infarction (AMI) in rats. [Methods] Myocardial infarction was induced by ligating the descending left coronary artery in male rats. Twenty-four hours later, 48 survived rats with MI were randomly divided into myocardial infarction (MI) control group, sham-operated group, Xinfukang middle dose group and Xinfukang high dose group. After 4 weeks of therapy, the cardiac function was measured. [Results] Compared with sham operated group, all the LVDd, LVDs, IVSd, IVSs, LVPWd and LVPWs, EF, CO, FS of treatment group were statistical different (P<0.05). The collagen fibers of sham operated group were increased and disordered. [Conclusions] Xinfukang can prevent LVRM after MI in rats, improve cardiac function, prohibit collagen fibers hyperplasia.