| 白念珠菌CDR1基因表达与氟康唑耐药的关系 |
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| 引用本文： | 贺志彬,廖万清,熊爱君,徐红,温海. 白念珠菌CDR1基因表达与氟康唑耐药的关系[J]. 上海医学, 2004, 27(2): 126-128 |
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| 作者姓名： | 贺志彬 廖万清 熊爱君 徐红 温海 |
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| 作者单位： | 200003,上海,第二军医大学长征医院皮肤科;江西省新余市新钢中心医院皮肤科 |
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| 摘 要： | 目的了解在白念珠菌氟康唑耐药或敏感菌株中CDR1基因的表达情况。方法抽提氟康唑耐药／敏感菌株的RNA,采用Northern blot技术观察CDR1基因的表达。结果白念珠菌耐药菌株CDR1基因的表达量明显高于对应的敏感菌株。结论白念珠菌CDR1基因的高表达与氟康唑耐药有关。
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| 关 键 词： | 白念珠菌 CDR1基因 氟康唑 耐药 |
Relevance of CDR1 gene expression of Candida albicans and fluconazole resistance |
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| HE Zhibin,LIAO Wanqing,XIONG Aijun,et al.. Relevance of CDR1 gene expression of Candida albicans and fluconazole resistance[J]. Shanghai Medical Journal, 2004, 27(2): 126-128 |
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| Authors: | HE Zhibin LIAO Wanqing XIONG Aijun et al. |
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| Affiliation: | HE Zhibin,LIAO Wanqing,XIONG Aijun,et al. Department of Dermatology,Changzheng Hospital,Second Military Medical University,Shanghai 200003,China |
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| Abstract: | Objective To explore the relevance of fluconazole resistance and expression of the CDR1 gene encoding the membrane transport proteins of the ABC transporter. Methods The RNA of fluconazole-susceptible and fluconazole-resistant Candida albicans isolates were extracted, and the expression of the CDR1 gene was observed by Northern blot method. Results Higher expression of CDR1 gene was observed in the fluconazole-resistant isolates than that on the fluconazole-susceptible isolates. Conclusions It is likely to suggest that over-expression of CDR1 gene of Candida albicans is relevant to fluconazole resistance. |
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| Keywords: | Candida albicans CDR1 gene Fluconazole Resistance |
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