The relapse risk of AML patients undergoing autologous transplantation correlates with the stem cell mobilizing potential |
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Authors: | von Grünigen Isabelle Raschle Joëlle Rüsges-Wolter Ilka Taleghani Behrouz Mansouri Mueller Beatrice U Pabst Thomas |
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Institution: | Department of Medical Oncology, University Hospital and University of Berne, Berne, Switzerland. |
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Abstract: | Autologous stem cell transplantation (ASCT) is widely used to consolidate first remission in AML. We determined the significance of circulating CD34+ cells at the day of blood stem cell collection in 78 AML patients. Patients mobilizing more than 60,000 CD34+ cells/ml had shorter overall survival (OS; P=0.0274), shorter time to progression (TTP; P=0.0014), and a higher relapse rate (P=0.0177). High levels of CD34+ cells were an independent marker for shorter OS and TTP in a multivariate analysis. These data suggest that ASCT is associated with unfavorable outcome in AML patients with high levels of mobilized peripheral CD34+ cells. |
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