甲基酪氨酸对实验性大鼠针刺镇痛作用的影响

<正> 很多实验证明中枢单胺类递质与针刺镇痛作用有关。我室对实验性电针镇痛的大鼠同时测定中枢单胺类递质表明,脑干的5-羟色脓增高,端脑去甲肾上腺素轻度下降。当用对氯苯丙氨酸耗竭脑内5-羟色胺时,可消除大鼠的针刺镇痛作用。北医针麻组也有类似的结果,而且证明5-羟色氨酸能加强针麻镇痛的效果。然而中枢儿茶酚胺在针刺镇痛中的作用比较复杂,实验报道较

THE EFFECT OF α--METHYLTYROSINE ON ELECTRO-ACUPUNCTURE ANALGESIA OF RAT

Rats that were not affected by acupuncture were selected and α-methyl- tyrosine (50mg/kg I.P.) in one dosage was given to inhibit the synthesis of catecholamine (CA) in CNS. Four hours after the injection the nore- epinephrine decreased by 45%, dopamine by 30% in three regions of the brains, respectively. Meantime, eletro--acupuncture was given to the animals. To compare with the control, the basic threshold of pain was no changed, aud also no change of the effect of acupuncture analgesia could be seen. The result suggested that the inhibition of the catecholamine sy- nthesis to decrease the level of CA in CNS is no effect on the acupunctu- re analgesia. The function of CA in CNS on the acupuncture analgesia n- eeds to use the more approaches to investigate further.