Effects of mycophenolic acid on high glucose-induced expression of TGF-beta and CTGF in mesangial cells. |
| |
| Authors: | Yongman Lü Junying Chen Jufang Shao |
| |
| Affiliation: | Department of Nephrology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan 430030, China. |
| |
| Abstract: | ![]()
The effects of mycophenolic acid (MPA) on high glucose-induced expression of transforming growth factor-beta (TGF-beta) and connective tissue growth factor (CTGF) in mesangial cells (MC) were investigated. Rat MC were cultured in the presence of different concentrations of MPA (1.0 and 10.0 micromol/L) or MPA plus high glucose for 72 h. The expression of TGF-beta and CTGF was detected by Western blot. The results showed that high glucose could induce the expression of TGF-beta and CTGF in MC, but MPA could inhibit this effects. MPA did not influence the expression of TGF-beta and CTGF in normal glucose. It was concluded that MPA might prevent the progression of diabetic nephropathy by inhibiting the expression of TGF-beta and CTGF in MC. |
| |
| Keywords: | |
|
|
