粘附分子CD44在膀胱移行细胞癌中异常表达

目的 研究粘附分子CD44v6和CD44s在膀胱移行细胞中的表达。方法 采用SP免疫组织化学染色方法对79例膀胱移行细胞癌手术切除标本进行研究。结果 （1）膀胱原位癌异常增生的上皮表达CD44v6和CD44s明显增强。（2）复发的Ⅰ、Ⅱ级膀胱癌CD44v6和CD44s的阳性表达率分别为90％（18／20）、40％（8／20）。（3）CD44v6和CD44s在浸润型膀胱癌的阳性率分别为43．1％（31／72）和13．9％（10／72）,且随癌细胞分化程度的降低和癌组织浸润深度的增加CD44v6表达减弱或消失。结论 CD44v6可能在膀胱移行细胞癌的形成和复发过程中发挥作用,而CD44v6表达减弱或消失则与癌细胞浸润生长和低分化有关。

The expression of CD44 in bladder transitional cell carcinomas

Objective To study the expression of CD44v6 and CD44s in bladder transitional cell carcinomas. Methods: The immunohistochemical staining of monoclonsl antibodies CD44v6 and CD44s were operated in 79 bladder transitional cell carinomas. Results (1) A strong expression of CD44v6 and CD44s were observed in atypical proliferation cells of bladder caricnoma in situ. (2) CD44v6 and CD44s expressed in recurrent I or Ⅱ grade transitional cell carcinomas were 90%(18/20) and 40%(8/20). (3) The positive expression rates of CD44v6 and CD44s were 43. 1%(31/72) and 13. 9%(10/72)in invasive transitional cell carcinomas; moreover, the expression of CD44v6 reduced with the poor differentiation and the deeply invasive growth of transitional eell carcinomas. Conclusion The investigation results suggested that CD44v6 played a role in the formation and recurrence of the bladder transitional cell carcinomas, but the reduced expression of CD44v6 probably related with the poor differentiation and invasive growth of the bladder transitional cell carcinomas.