HIV-1/AIDS患者血清铁蛋白与病情进展关系的研究

目的了解HIV-1／AIDS病人血清铁蛋白检测结果与HIV／AIDS患者病情进展的关系。方法使用化学发光法（CLIA）检测已确诊的24例HIV-1阳性患者血清铁蛋白,结合患者的临床资料和其他检验结果,对不同临床分期、贫血程度和消瘦程度的HIV／AIDS患者的血清铁蛋白水平进行分析。结果在24例HIV／AIDS病人中,不同临床分期的患者血清铁蛋白水平比较有统计学差异,AIDS组明显高于ARC组,ARC组明显高于AS组;在不同消瘦程度的组别中存在统计学差异,中度和重度体重减轻的患者铁蛋白水平明显高于体重正常和体重轻度、中度减轻的患者;在不同的贫血组别中存在明显差异,中度和重度贫血组的铁蛋白水平明显高于无贫血患者和轻度贫血者。结论在不同的疾病进展阶段,铁蛋白的水平存在着显著性差异,铁蛋白水平随着病情的进展而升高。铁蛋白是提示HIV／AIDS进展的灵敏指标。

Relationship Between Serum Ferritin Levels and HIV-1/AIDS Clinical Advances

Objective To investigate the relationship between serum ferritin levels and clinical advances in patients suffered HIV_(-1)/AIDS. Methods Serum ferritin levels were assayed in 24 patients suffering from HIV_(-1)/AIDS by Chemiluminescent Immunoassay (CLIA) method, and the correlations with severity of anemia and weight loss were evaluated in different clinical stages of the disease combined with other clinical and laboratory data. Result The AIDS patient group had the highest serum ferritin levels as compared with the ARC and AS patient groups (P<0.01), and ARC group was higher than AS group (P<0.01). In patients with weight losses of different degree, the serious weight loss group had the highest serum ferritin concentrations as compared to the mild weight loss or normal groups (P<0.01). Serious and moderate anemia patients had higher serum ferritin level as compared with patients with mild or no anemia groups (P<0.01 or P<0.05). Conclusion The levels of serum ferritin rose with pathophysiologic deterioration in the HIV_(-1)/AIDS patients. Serum Ferritin level is a good indicator for the pathological progressive processes of HIV_(-1)/AIDS.