| 维甲酸对甲状腺癌细胞钠/碘转运体基因的调节作用 |
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| 引用本文： | 刘超,李倩,段宇,覃又文,刘翠萍,武晓泓,蒋须勤. 维甲酸对甲状腺癌细胞钠/碘转运体基因的调节作用[J]. 中华内分泌代谢杂志, 2004, 20(4): 302-303 |
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| 作者姓名： | 刘超 李倩 段宇 覃又文 刘翠萍 武晓泓 蒋须勤 |
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| 作者单位： | 210029,南京医科大学第一附属医院内分泌科 |
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| 基金项目： | 国家自然科学发展基金资助(39970351) |
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| 摘 要： | 以RTPCR法检测维甲酸对甲状腺癌细胞钠/碘转运体(NIS)基因表达的影响,发现在5～50μmol/L的剂量区间,维甲酸能促进NIS基因表达,提示维甲酸在甲状腺癌及其转移灶的治疗中可能起到重要作用。
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| 关 键 词： | 甲状腺癌 细胞 钠/碘转运体 维甲酸 基因表达 |
| 修稿时间： | 2003-06-19 |
Regulation of retinoic acid on sodium iodide symporter gene expression in thyroid carcinoma cells |
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| LIU Chao,Li Qian,DUAN Yu,QIN You-wen,LIU Cui-ping,WU Xiao-hong,JIANG Xu-qing. Regulation of retinoic acid on sodium iodide symporter gene expression in thyroid carcinoma cells[J]. Chinese Journal of Endocrinology and Metabolism, 2004, 20(4): 302-303 |
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| Authors: | LIU Chao Li Qian DUAN Yu QIN You-wen LIU Cui-ping WU Xiao-hong JIANG Xu-qing |
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| Affiliation: | LIU Chao~*,Li Qian,DUAN Yu,QIN You-wen,LIU Cui-ping,WU Xiao-hong,JIANG Xu-qing. ~*Department of Endocrinology,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029 |
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| Abstract: | The influence of retinoic acid on the expression of sodium iodide symporter gene was assayed in thyroid carcinoma cells by RT-PCR. The result showed that retinoic acid significantly stimulated the expression of the sodium iodide symporter gene in thyroid carcinoma cells, suggesting that retinoic acid seems to play an important role in the therapy of thyroid cancer remnant or metastasis. |
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| Keywords: | Thyroid carcinoma Cells Sodium iodide symporter Retinoic acid Gene expression |
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