| 犬肝硬化门静脉高压征食管静脉曲张模型的建立及评价 |
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| 引用本文： | 王艳梅,李楠,王雅文,王欣,张林. 犬肝硬化门静脉高压征食管静脉曲张模型的建立及评价[J]. 临床军医杂志, 2008, 36(5) |
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| 作者姓名： | 王艳梅 李楠 王雅文 王欣 张林 |
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| 作者单位： | 解放军总医院第二附属医院,消化科,北京,100091;解放军总医院第二附属医院,消化科,北京,100091;解放军总医院第二附属医院,消化科,北京,100091;解放军总医院第二附属医院,消化科,北京,100091;解放军总医院第二附属医院,消化科,北京,100091 |
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| 摘 要： | 目的食管胃底静脉曲张动物模型的建立,对研究如何预防和治疗门脉高压征食管胃底静脉曲张出血具有重要意义。本研究目的在于建立犬门脉高压征食管静脉曲张动物模型并加以评价,为下一步探索临床治疗方法提供可靠、稳定的模型动物。方法10条健康成年雄性杂种犬为研究对象,以胆总管结扎术加CCl4法建立门脉高压征食管胃底静脉曲张动物模型。同时采用一系列的检查方法加以评估。结果10条犬存活8条,经胃镜检查证实,所有存活动物均形成食管静脉曲张,其中轻度2例,中度4例,重度2例。与术前相比,肝功能显著异常,门静脉压力明显升高,差异具有显著统计学意义(P<0.01)。门脉高压性胃病达58%。结论本组方法简单易行,模型质量可靠,制备周期明显缩短。该方法可形成稳定的肝硬化门脉高压征食管静脉曲张模型,可用于该方面的相关研究。
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| 关 键 词： | 犬 动物模型 食管静脉曲张 门脉高压征 |
Establishment and Evaluation of Esophageal Varices in Dogs with Portal Hypertension |
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| Wang Yan-mei,Li Nan,Wang Ya-wen,Wang Xin,Zhang Lin. Establishment and Evaluation of Esophageal Varices in Dogs with Portal Hypertension[J]. Clinical Journal of Medical Officer, 2008, 36(5) |
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| Authors: | Wang Yan-mei Li Nan Wang Ya-wen Wang Xin Zhang Lin |
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| Affiliation: | Wang Yan-mei,Li Nan,Wang Ya-wen,Wang Xin,Zhang Lin(Department of Gastroenterology,Second Affiliated Hospital of PLA General Hospital,Beijing 100091,China) |
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| Abstract: | Objective To develop and evaluate the canine model of esophageal varices with portal hypertension for successive study on the treatment of bleeding caused by esophageal varices.Methods Ten healthy adult mongrel dogs were used in the study.Esophageal varices were established by complete ligation of common bile duct and injection of CCL4.Results After operation,8 in 10 dogs survived for six to eight weeks.All the dogs who survived had developed esophageal varices that were demonstrated by endoscopy,i.e.mild i... |
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| Keywords: | canine animal model esophageal varices portal hypertension |
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