多巴胺D4受体基因与强迫症的关联

目的：探讨多巴胺D4受体DRD4基因多态性同强迫症（OCD）的关系。方法：采用PCR-AmFLP技术测定105例OCD患者和100例健康对照者的DRD4基因48bp可变数目重复序列的多态性。结果：OCD组与对照组间等位基因频数分布差异显著（P〈0.05）;其中患者组在4倍48bp重复序列纯合子的分布上明显低于对照组（P〈0.05）。结论：DRD4基因48bp可变数目重复序列的多态性可能与强迫症的发病有关。

Dopamine receptor D4 gene polymorphism and obsessive-compulsive disorder

Objective: To investigate the relationship between polymorphism of dopamine receptor D4 (DRD4) gene and obsessive-compulsive disorder (OCD). Method:105 OCD patients and 100 healthy controls were enrolled.All subjects were genotyped directly by polymerase chain reaction amplification fragment length polymorphism techniques. Results:There were significant differences of allele frequencies of DRD4 between OCD patients and controls(P<0.05),a lower frequency of the homozygote 4R in OCD patients compared to normal controls (P<0.05). Conclusion:The polymorphism of DRD4 receptor gene may be associated with OCD.