Prostaglandin-Independent Stimulation of Interleukin-6 Production by Fibrinogen Degradation Product D in Perfused Murine Liver |
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| Authors: | Csala,Lé rá nt,Bá nhegyi,Kardon,Puská s,Mucha,Machovich,Falus,& Mandl |
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| Affiliation: | Department of Medical Chemistry, Semmelweis University of Medicine, Budapest, Hungary,;Department of Medical Biochemistry, Semmelweis University of Medicine, Budapest, Hungary,;Institute of Isotopes, Budapest, Hungary,;Department of Genetics, Cell and Immunobiology, Semmelweis University of Medicine, Budapest, Hungary |
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| Abstract: | ![]()
Bacterial endotoxin (LPS) and fibrinogen degradation product D (FDP-D) are both potent stimulators of interleukin-6 (IL-6) production in liver, however, there are differences in their metabolic effects. The aim of the present study was to compare the role of prostaglandins in the enhancement of IL-6 production by LPS or FDP-D in perfused mouse livers. Indomethacin inhibited the effect of LPS significantly but was ineffective in the case of FDP-D. Accordingly, production of prostaglandins D2 and E2 was not elevated following the addition of FDP-D, while their formation was increased several fold by LPS. At the same time interleukin-1 (IL-1) production in perfused liver rose markedly upon the addition of FDP-D. It is suggested that prostaglandins are not involved in the effects of FDP-D on the liver. The stimulatory effect of FDP-P on IL-6 production might be the consequence of elevated IL-1 levels. |
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