|
|||||
|
|
| 复方5—氟脲嘧啶静脉注射用乳剂体内分布及药物动力学研究 | |
| 引用本文： | 陈济氏,姚崇舜,李志江,庄继生. 复方5—氟脲嘧啶静脉注射用乳剂体内分布及药物动力学研究[J]. 沈阳药科大学学报, 1984, 0(2) |
| 作者姓名： | 陈济氏 姚崇舜 李志江 庄继生 |
| 作者单位： | 沈阳药学院，沈阳药学院，安阳第一制药厂，安阳第一制药厂 |
| 摘 要： | 复方静脉乳剂静脉注射后,在家兔体内药物动力学特征呈现为双隔室开放模型,α=0.343分~(-1),t_1/2α=2分,β=0.0672分~(-1),t_1/2β=10.3分。小白鼠静注后,在小肠、直肠、脾、胃组织中维持较长时间,2小时后仍有可测得的浓度。 |
| 关 键 词： | 5-氟脲啶嘧 乳剂 药物动力学 体内分布 |
STUDIES ON DISTRIBUTION IN THE BODY AND PHARMACOKINETICS OF 5-FLUOROURACIL COMPOSITE EMULSION FOR INTRAVENOUS INJECTION |
|
| Chen Jimin Yao Chongshun Shenyang College of pharmacy Li Zhijiang Zhuang Jisheng Anyan The First Pharmaceutical Factory. STUDIES ON DISTRIBUTION IN THE BODY AND PHARMACOKINETICS OF 5-FLUOROURACIL COMPOSITE EMULSION FOR INTRAVENOUS INJECTION[J]. Journal of Shenyang Pharmaceutical University, 1984, 0(2) | |
| Authors: | Chen Jimin Yao Chongshun Shenyang College of pharmacy Li Zhijiang Zhuang Jisheng Anyan The First Pharmaceutical Factory |
| Affiliation: | Chen Jimin Yao Chongshun Shenyang College of pharmacy Li Zhijiang Zhuang Jisheng Anyan The First Pharmaceutical Factory |
| Abstract: | After intravenous administration of 5-fluorouracil composite emulsion in rabbits, 5-fluorouracil confers the pharmacokinetic characteristics of a two-compartment model on body. α=0.343min~(-1), t_(1/2α)=2min, β=0.0672min~(-1), t_(1/2β)=10.3min. After intravenous administration in mice, the tissue distribution of 5-fluorouracil shows that it maintains a longer period in small intestine,straight intestine,spleen, stomach, and still has a determinable level after 2 hours. |
| Keywords: | Fluorouracil Emulsion Pharmacokinetics Distribution |
| 本文献已被 CNKI 等数据库收录！ | |